Revised 2017 international consensus on testing of ANCAs in granulomatosis with polyangiitis and microscopic polyangiitis

Xavier Bossuyt*, Jan-Willem Cohen Tervaert, Yoshihiro Arimura, Daniel Blockmans, Luis Felipe Flores-Suarez, Loic Guillevin, Bernhard Hellmich, J. Charles Jennette, Cees G. M. Kallenberg, Sergey Moiseev, Pavel Novikov, Antonella Radice, Judith Anne Savige, Renato Alberto Sinico, Ulrich Specks, Pieter van Paassen, Ming-hui Zhao, Niels Rasmussen, Jan Damoiseaux, Elena CsernokDavid Jayne

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

171 Citations (Web of Science)

Abstract

Anti-neutrophil cytoplasmic antibodies (ANCAs) are valuable laboratory markers used for the diagnosis of well-defined types of small-vessel vasculitis, including granulomatosis with polyangiitis (GPA) and microscopic polyangiitis (MPA). According to the 1999 international consensus on ANCA testing, indirect immunofluorescence (IIF) should be used to screen for ANCAs, and samples containing ANCAs should then be tested by immunoassays for proteinase 3 (PR3)-ANCAs and myeloperoxidase (MPO)-ANCAs. The distinction between PR3-ANCAs and MPO-ANCAs has important clinical and pathogenic implications. As dependable immunoassays for PR3-ANCAs and MPO-ANCAs have become broadly available, there is increasing international agreement that high-quality immunoassays are the preferred screening method for the diagnosis of ANCA-associated vasculitis. The present Consensus Statement proposes that high-quality immunoassays can be used as the primary screening method for patients suspected of having the ANCA-associated vaculitides GPA and MPA without the categorical need for IIF, and presents and discusses evidence to support this recommendation.

Original languageEnglish
Pages (from-to)683-692
Number of pages10
JournalNature Reviews Rheumatology
Volume13
Issue number11
DOIs
Publication statusPublished - Nov 2017

Keywords

  • ANTINEUTROPHIL CYTOPLASMIC ANTIBODIES
  • INFLAMMATORY-BOWEL-DISEASE
  • SMALL-VESSEL VASCULITIS
  • LINKED-IMMUNOSORBENT-ASSAY
  • RHEUMATOLOGY 1990 CRITERIA
  • ANTI-MPO ANTIBODIES
  • WEGENERS-GRANULOMATOSIS
  • SYSTEMIC VASCULITIS
  • FOLLOW-UP
  • INDIRECT IMMUNOFLUORESCENCE

Cite this