Review: ischaemia-reperfusion injury in flap surgery

M.G. van den Heuvel*, W.A. Buurman, A. Bast, R.R. van der Hulst

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review


    Ischaemia-reperfusion injury is the mechanism underlying (partial) flap loss. This is not only a traumatic event for the patient, it also causes increased patient morbidity [Kerrigan CL, Stotland MA. Ischemia reperfusion injury: a review. Microsurgery 1993;14:165-75] as well as prolonged hospitalisation, increasing medical consumption and costs. For surgeons who perform flap surgery, it is important to have knowledge of ischaemia-reperfusion injury in order to prevent it. In this article, an update on the recent research on ischaemia-reperfusion is given. The production of reactive oxygen species, neutrophil influx, depletion of NO and apoptosis are discussed as well.
    Original languageEnglish
    Pages (from-to)721-726
    JournalJournal of Plastic Reconstructive and Aesthetic Surgery
    Issue number6
    Publication statusPublished - 1 Jan 2009

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