Ischaemia-reperfusion injury is the mechanism underlying (partial) flap loss. This is not only a traumatic event for the patient, it also causes increased patient morbidity [Kerrigan CL, Stotland MA. Ischemia reperfusion injury: a review. Microsurgery 1993;14:165-75] as well as prolonged hospitalisation, increasing medical consumption and costs. For surgeons who perform flap surgery, it is important to have knowledge of ischaemia-reperfusion injury in order to prevent it. In this article, an update on the recent research on ischaemia-reperfusion is given. The production of reactive oxygen species, neutrophil influx, depletion of NO and apoptosis are discussed as well.
|Journal||Journal of Plastic Reconstructive and Aesthetic Surgery|
|Publication status||Published - 1 Jan 2009|
van den Heuvel, M. G., Buurman, W. A., Bast, A., & van der Hulst, R. R. (2009). Review: ischaemia-reperfusion injury in flap surgery. Journal of Plastic Reconstructive and Aesthetic Surgery, 62(6), 721-726. https://doi.org/10.1016/j.bjps.2009.01.060