TY - JOUR
T1 - Review: ischaemia-reperfusion injury in flap surgery
AU - van den Heuvel, M.G.
AU - Buurman, W.A.
AU - Bast, A.
AU - van der Hulst, R.R.
PY - 2009/1/1
Y1 - 2009/1/1
N2 - Ischaemia-reperfusion injury is the mechanism underlying (partial) flap loss. This is not only a traumatic event for the patient, it also causes increased patient morbidity [Kerrigan CL, Stotland MA. Ischemia reperfusion injury: a review. Microsurgery 1993;14:165-75] as well as prolonged hospitalisation, increasing medical consumption and costs. For surgeons who perform flap surgery, it is important to have knowledge of ischaemia-reperfusion injury in order to prevent it. In this article, an update on the recent research on ischaemia-reperfusion is given. The production of reactive oxygen species, neutrophil influx, depletion of NO and apoptosis are discussed as well.
AB - Ischaemia-reperfusion injury is the mechanism underlying (partial) flap loss. This is not only a traumatic event for the patient, it also causes increased patient morbidity [Kerrigan CL, Stotland MA. Ischemia reperfusion injury: a review. Microsurgery 1993;14:165-75] as well as prolonged hospitalisation, increasing medical consumption and costs. For surgeons who perform flap surgery, it is important to have knowledge of ischaemia-reperfusion injury in order to prevent it. In this article, an update on the recent research on ischaemia-reperfusion is given. The production of reactive oxygen species, neutrophil influx, depletion of NO and apoptosis are discussed as well.
U2 - 10.1016/j.bjps.2009.01.060
DO - 10.1016/j.bjps.2009.01.060
M3 - Article
C2 - 19299216
SN - 1748-6815
VL - 62
SP - 721
EP - 726
JO - Journal of Plastic Reconstructive and Aesthetic Surgery
JF - Journal of Plastic Reconstructive and Aesthetic Surgery
IS - 6
ER -