Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage

Adrian R. Parry-Jones; Mario Di Napoli; Joshua N. Goldstein; Floris H. B. M. Schreuder; Sami Tetri; Turgut Tatlisumak; Bernard Yan; Koen M. van Nieuwenhuizen; Nelly Dequatre-Ponchelle; Matthew Lee-Archer; Solveig Horstmann; Duncan Wilson; Fulvio Pomero; Luca Masotti; Christine Lerpiniere; Daniel Agustin Godoy; Abigail S. Cohen; Rik Houben; Rustam Al-Shahi Salman; Paolo Pennati; Luigi Fenoglio; David Werring; Roland Veltkamp; Edith Wood; Helen M. Dewey; Charlotte Cordonnier; Catharina J. M. Klijn; Fabrizio Meligeni; Stephen M. Davis; Juha Huhtakangas; Julie Staals; Jonathan Rosand; Atte Meretoja

doi:10.1002/ana.24416

Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage

Adrian R. Parry-Jones
, Mario Di Napoli
, Joshua N. Goldstein
, Floris H. B. M. Schreuder
, Sami Tetri
, Turgut Tatlisumak
, Bernard Yan
, Koen M. van Nieuwenhuizen
, Nelly Dequatre-Ponchelle
, Matthew Lee-Archer
, Solveig Horstmann
, Duncan Wilson
, Fulvio Pomero
, Luca Masotti
, Christine Lerpiniere
, Daniel Agustin Godoy
, Abigail S. Cohen
, Rik Houben
, Rustam Al-Shahi Salman
, Paolo Pennati

Luigi Fenoglio, David Werring, Roland Veltkamp, Edith Wood, Helen M. Dewey, Charlotte Cordonnier, Catharina J. M. Klijn, Fabrizio Meligeni, Stephen M. Davis, Juha Huhtakangas, Julie Staals, Jonathan Rosand, Atte Meretoja^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case fatality with different reversal strategies. MethodsWe pooled individual ICH patient data from 16 stroke registries in 9 countries (n=10 282), of whom 1,797 (17%) were on VKA. After excluding 250 patients with international normalized ratio

Original language	English
Pages (from-to)	54-62
Number of pages	9
Journal	Annals of Neurology
Volume	78
Issue number	1
DOIs	https://doi.org/10.1002/ana.24416
Publication status	Published - Jul 2015

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Parry-Jones, A. R., Di Napoli, M., Goldstein, J. N., Schreuder, F. H. B. M., Tetri, S., Tatlisumak, T., Yan, B., van Nieuwenhuizen, K. M., Dequatre-Ponchelle, N., Lee-Archer, M., Horstmann, S., Wilson, D., Pomero, F., Masotti, L., Lerpiniere, C., Godoy, D. A., Cohen, A. S., Houben, R., Al-Shahi Salman, R., ... Meretoja, A. (2015). Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage. Annals of Neurology, 78(1), 54-62. https://doi.org/10.1002/ana.24416

@article{b5bb626bff7b45238879cf4a97341b15,

title = "Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage",

abstract = "Objective There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case fatality with different reversal strategies. MethodsWe pooled individual ICH patient data from 16 stroke registries in 9 countries (n=10 282), of whom 1,797 (17\%) were on VKA. After excluding 250 patients with international normalized ratio",

author = "Parry-Jones, \{Adrian R.\} and \{Di Napoli\}, Mario and Goldstein, \{Joshua N.\} and Schreuder, \{Floris H. B. M.\} and Sami Tetri and Turgut Tatlisumak and Bernard Yan and \{van Nieuwenhuizen\}, \{Koen M.\} and Nelly Dequatre-Ponchelle and Matthew Lee-Archer and Solveig Horstmann and Duncan Wilson and Fulvio Pomero and Luca Masotti and Christine Lerpiniere and Godoy, \{Daniel Agustin\} and Cohen, \{Abigail S.\} and Rik Houben and \{Al-Shahi Salman\}, Rustam and Paolo Pennati and Luigi Fenoglio and David Werring and Roland Veltkamp and Edith Wood and Dewey, \{Helen M.\} and Charlotte Cordonnier and Klijn, \{Catharina J. M.\} and Fabrizio Meligeni and Davis, \{Stephen M.\} and Juha Huhtakangas and Julie Staals and Jonathan Rosand and Atte Meretoja",

year = "2015",

month = jul,

doi = "10.1002/ana.24416",

language = "English",

volume = "78",

pages = "54--62",

journal = "Annals of Neurology",

issn = "0364-5134",

publisher = "John Wiley \& Sons Inc.",

number = "1",

}

Parry-Jones, AR, Di Napoli, M, Goldstein, JN, Schreuder, FHBM, Tetri, S, Tatlisumak, T, Yan, B, van Nieuwenhuizen, KM, Dequatre-Ponchelle, N, Lee-Archer, M, Horstmann, S, Wilson, D, Pomero, F, Masotti, L, Lerpiniere, C, Godoy, DA, Cohen, AS, Houben, R, Al-Shahi Salman, R, Pennati, P, Fenoglio, L, Werring, D, Veltkamp, R, Wood, E, Dewey, HM, Cordonnier, C, Klijn, CJM, Meligeni, F, Davis, SM, Huhtakangas, J, Staals, J, Rosand, J & Meretoja, A 2015, 'Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage', Annals of Neurology, vol. 78, no. 1, pp. 54-62. https://doi.org/10.1002/ana.24416

TY - JOUR

T1 - Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage

AU - Parry-Jones, Adrian R.

AU - Di Napoli, Mario

AU - Goldstein, Joshua N.

AU - Schreuder, Floris H. B. M.

AU - Tetri, Sami

AU - Tatlisumak, Turgut

AU - Yan, Bernard

AU - van Nieuwenhuizen, Koen M.

AU - Dequatre-Ponchelle, Nelly

AU - Lee-Archer, Matthew

AU - Horstmann, Solveig

AU - Wilson, Duncan

AU - Pomero, Fulvio

AU - Masotti, Luca

AU - Lerpiniere, Christine

AU - Godoy, Daniel Agustin

AU - Cohen, Abigail S.

AU - Houben, Rik

AU - Al-Shahi Salman, Rustam

AU - Pennati, Paolo

AU - Fenoglio, Luigi

AU - Werring, David

AU - Veltkamp, Roland

AU - Wood, Edith

AU - Dewey, Helen M.

AU - Cordonnier, Charlotte

AU - Klijn, Catharina J. M.

AU - Meligeni, Fabrizio

AU - Davis, Stephen M.

AU - Huhtakangas, Juha

AU - Staals, Julie

AU - Rosand, Jonathan

AU - Meretoja, Atte

PY - 2015/7

Y1 - 2015/7

N2 - Objective There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case fatality with different reversal strategies. MethodsWe pooled individual ICH patient data from 16 stroke registries in 9 countries (n=10 282), of whom 1,797 (17%) were on VKA. After excluding 250 patients with international normalized ratio

AB - Objective There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case fatality with different reversal strategies. MethodsWe pooled individual ICH patient data from 16 stroke registries in 9 countries (n=10 282), of whom 1,797 (17%) were on VKA. After excluding 250 patients with international normalized ratio

U2 - 10.1002/ana.24416

DO - 10.1002/ana.24416

M3 - Article

C2 - 25857223

SN - 0364-5134

VL - 78

SP - 54

EP - 62

JO - Annals of Neurology

JF - Annals of Neurology

IS - 1

ER -

Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage

Abstract

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