Reversal strategies for vitamin K antagonists in acute intracerebral hemorrhage

Adrian R. Parry-Jones, Mario Di Napoli, Joshua N. Goldstein, Floris H. B. M. Schreuder, Sami Tetri, Turgut Tatlisumak, Bernard Yan, Koen M. van Nieuwenhuizen, Nelly Dequatre-Ponchelle, Matthew Lee-Archer, Solveig Horstmann, Duncan Wilson, Fulvio Pomero, Luca Masotti, Christine Lerpiniere, Daniel Agustin Godoy, Abigail S. Cohen, Rik Houben, Rustam Al-Shahi Salman, Paolo PennatiLuigi Fenoglio, David Werring, Roland Veltkamp, Edith Wood, Helen M. Dewey, Charlotte Cordonnier, Catharina J. M. Klijn, Fabrizio Meligeni, Stephen M. Davis, Juha Huhtakangas, Julie Staals, Jonathan Rosand, Atte Meretoja*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

64 Citations (Web of Science)

Abstract

Objective There is little evidence to guide treatment strategies for intracerebral hemorrhage on vitamin K antagonists (VKA-ICH). Treatments utilized in clinical practice include fresh frozen plasma (FFP) and prothrombin complex concentrate (PCC). Our aim was to compare case fatality with different reversal strategies. MethodsWe pooled individual ICH patient data from 16 stroke registries in 9 countries (n=10 282), of whom 1,797 (17%) were on VKA. After excluding 250 patients with international normalized ratio
Original languageEnglish
Pages (from-to)54-62
JournalAnnals of Neurology
Volume78
Issue number1
DOIs
Publication statusPublished - Jul 2015

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