TY - JOUR
T1 - Revealing the significance of IL-2 and IL-5 in SARS-CoV-2-specific T-cell responses in kidney transplant recipients
AU - den Hartog, Yvette
AU - Malahe, S. Reshwan K.
AU - Rietdijk, Wim J.R.
AU - Dieterich, Marjolein
AU - Gommers, Lennert
AU - van Baarle, Debbie
AU - Diavatopoulos, Dimitri A.
AU - Messchendorp, A. Lianne
AU - van der Molen, Renate G.
AU - Remmerswaal, Ester B.M.
AU - Bemelman, Frederike J.
AU - Kho, Marcia M.L.
AU - GeurtsvanKessel, Corine H.
AU - Koopmans, Marion P.G.
AU - Gansevoort, Ron T.
AU - Hilbrands, Luuk B.
AU - Sanders, Jan Stephan
AU - Reinders, Marlies E.J.
AU - Baan, Carla C.
AU - de Vries, Rory D.
AU - van Binnendijk, Rob
AU - den Hartog, Gerco
AU - Rots, Nynke
AU - van Mourik, Djenolan
AU - Philipsen, Ria
AU - Mattheussens, Wouter B.
AU - Boer-Verschragen, Marieken J.
AU - Adema, Yvonne M.R.
AU - Vart, Priya
AU - Imhof, Celine
AU - van der Heiden, Marieke
AU - Standaar, Dorien
AU - Frölke, Sophie C.
AU - ten Dam, Marc A.G.J.
AU - Hemmelder, Marc H.
AU - Bouwmans, Pim
AU - Baas, Marije C.
AU - Abrahams, Alferso C.
AU - RECOVAC Consortium
N1 - Funding Information:
We would like to thank all participants of the RECOVAC study. This research was funded by the Netherlands Organization for Health Research and Development (ZonMw), grant agreement: 10430072010002. This study was also supported by the Dutch Kidney Foundation (project 21OP\u2009+\u2009036 and CP1801). The Erasmus MC HCW was financially supported by the ZonMw grant agreement 10150062010008 and 10430072110001, the Health~Holland grant EMCLHS20017 and LSHM19136, co-funded by the PPP Allowance made available by the Health~Holland, Top Sector Life Sciences & Health, to stimulate public \u2013private partnerships, and the European Union\u2019s Horizon 2020 research and innovation program under grant number 101003589 (RECoVER). Funders had no role in the design of the study, data interpretation, writing of the manuscript nor in the decision to submit the manuscript.
Publisher Copyright:
© The Author(s) 2024.
PY - 2024/12/1
Y1 - 2024/12/1
N2 - Kidney transplant recipients (KTRs) are at an increased risk of severe COVID-19 due to compromised immune responses. Although vaccination is critical in preventing severe disease, KTRs have attenuated vaccination-induced immune responses due to underlying kidney disease and immunosuppressive therapies. In this study, the effect of different COVID-19 booster strategies on SARS-CoV-2-specific T-cell responses was assessed in KTRs who showed a poor serological response after the first two mRNA-based primary vaccination doses. In these KTRs, a third vaccination dose led to an increase in antibody levels in the majority of patients. Production of IL-2 and IL-5 by SARS-CoV-2 specific T cells positively correlated with antibody levels, with stronger correlations compared to IFN-? production, the ‘traditional’ cytokine to measure T-cell responses. Our study underscores the significance a balanced T-cell cytokine response to achieve robust antibody responses in KTRs. Furthermore, we show that multiple cytokines to assess T-cell responses should be explored to identify individuals in need of tailored vaccination strategies.
AB - Kidney transplant recipients (KTRs) are at an increased risk of severe COVID-19 due to compromised immune responses. Although vaccination is critical in preventing severe disease, KTRs have attenuated vaccination-induced immune responses due to underlying kidney disease and immunosuppressive therapies. In this study, the effect of different COVID-19 booster strategies on SARS-CoV-2-specific T-cell responses was assessed in KTRs who showed a poor serological response after the first two mRNA-based primary vaccination doses. In these KTRs, a third vaccination dose led to an increase in antibody levels in the majority of patients. Production of IL-2 and IL-5 by SARS-CoV-2 specific T cells positively correlated with antibody levels, with stronger correlations compared to IFN-? production, the ‘traditional’ cytokine to measure T-cell responses. Our study underscores the significance a balanced T-cell cytokine response to achieve robust antibody responses in KTRs. Furthermore, we show that multiple cytokines to assess T-cell responses should be explored to identify individuals in need of tailored vaccination strategies.
U2 - 10.1038/s44298-024-00015-7
DO - 10.1038/s44298-024-00015-7
M3 - Article
VL - 2
JO - Npj Viruses
JF - Npj Viruses
IS - 1
M1 - 7
ER -