Retinal pigment epithelium-secretome: A diabetic retinopathy perspective

Ponnalagu Murugeswari; Murali Subramani; Chaitra Jayadev; Rohit Shetty; Debashish Das

doi:10.1016/j.cyto.2017.02.013

Retinal pigment epithelium-secretome: A diabetic retinopathy perspective

Ponnalagu Murugeswari, Murali Subramani, Chaitra Jayadev, Rohit Shetty, Debashish Das^*

^*Corresponding author for this work

Research output: Contribution to journal › (Systematic) Review article › peer-review

Abstract

Diabetic retinopathy is a major complication of diabetes mellitus that can lead to retinal vascular abnormalities and visual impairment. While retinal endothelial pathology is well studied, retinal pigment epithelium (RPE) layer modifications and the patho-physiological regulations are not widely understood. The RPE is a highly specialized pigmented layer regulating not only physiological functions such as transport of nutrients, ions, absorption of light, phagocytosis of photoreceptor membranes, but also secretion of a number of cytokines, chemokines, angiogenic and anti-angiogenic factors. The RPE secretome, though crucial in health and disease, remains elusive in diabetic retinopathy. A knowledge of these secreted factors would help explain and correlate the clinical phase of the disease aiding in improved disease management. A comprehensive knowledge of the secreted factors of the RPE is a potential tool for understanding the differential treatment regime of early diabetic retinopathy, diabetic proliferative retinopathy and diabetic macular edema. In this review, we have delineated the importance of factors secreted by the retinal pigment epithelium and its regulation in the pathogenesis of diabetic retinopathy. (C) 2017 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	126-135
Number of pages	10
Journal	Cytokine
Volume	95
DOIs	https://doi.org/10.1016/j.cyto.2017.02.013
Publication status	Published - Jul 2017

Keywords

Retinal pigment epithelium
Secretory factors
Diabetic retinopathy
VEGF
Neovascularization
Cytokines
ENDOTHELIAL GROWTH-FACTOR
MACULAR EDEMA
GENE-EXPRESSION
HIGH GLUCOSE
ERYTHROPOIETIN PROTECTS
OXIDATIVE STRESS
INTERPHOTORECEPTOR MATRIX
INTRAVITREAL BEVACIZUMAB
BARRIER BREAKDOWN
VISUAL FUNCTION

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10.1016/j.cyto.2017.02.013

Cite this

@article{e874941e49aa41e2a311ee9a00d38dfb,

title = "Retinal pigment epithelium-secretome: A diabetic retinopathy perspective",

abstract = "Diabetic retinopathy is a major complication of diabetes mellitus that can lead to retinal vascular abnormalities and visual impairment. While retinal endothelial pathology is well studied, retinal pigment epithelium (RPE) layer modifications and the patho-physiological regulations are not widely understood. The RPE is a highly specialized pigmented layer regulating not only physiological functions such as transport of nutrients, ions, absorption of light, phagocytosis of photoreceptor membranes, but also secretion of a number of cytokines, chemokines, angiogenic and anti-angiogenic factors. The RPE secretome, though crucial in health and disease, remains elusive in diabetic retinopathy. A knowledge of these secreted factors would help explain and correlate the clinical phase of the disease aiding in improved disease management. A comprehensive knowledge of the secreted factors of the RPE is a potential tool for understanding the differential treatment regime of early diabetic retinopathy, diabetic proliferative retinopathy and diabetic macular edema. In this review, we have delineated the importance of factors secreted by the retinal pigment epithelium and its regulation in the pathogenesis of diabetic retinopathy. (C) 2017 Elsevier Ltd. All rights reserved.",

keywords = "Retinal pigment epithelium, Secretory factors, Diabetic retinopathy, VEGF, Neovascularization, Cytokines, ENDOTHELIAL GROWTH-FACTOR, MACULAR EDEMA, GENE-EXPRESSION, HIGH GLUCOSE, ERYTHROPOIETIN PROTECTS, OXIDATIVE STRESS, INTERPHOTORECEPTOR MATRIX, INTRAVITREAL BEVACIZUMAB, BARRIER BREAKDOWN, VISUAL FUNCTION",

author = "Ponnalagu Murugeswari and Murali Subramani and Chaitra Jayadev and Rohit Shetty and Debashish Das",

year = "2017",

month = jul,

doi = "10.1016/j.cyto.2017.02.013",

language = "English",

volume = "95",

pages = "126--135",

journal = "Cytokine",

issn = "1043-4666",

publisher = "Elsevier Science",

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TY - JOUR

T1 - Retinal pigment epithelium-secretome

T2 - A diabetic retinopathy perspective

AU - Murugeswari, Ponnalagu

AU - Subramani, Murali

AU - Jayadev, Chaitra

AU - Shetty, Rohit

AU - Das, Debashish

PY - 2017/7

Y1 - 2017/7

N2 - Diabetic retinopathy is a major complication of diabetes mellitus that can lead to retinal vascular abnormalities and visual impairment. While retinal endothelial pathology is well studied, retinal pigment epithelium (RPE) layer modifications and the patho-physiological regulations are not widely understood. The RPE is a highly specialized pigmented layer regulating not only physiological functions such as transport of nutrients, ions, absorption of light, phagocytosis of photoreceptor membranes, but also secretion of a number of cytokines, chemokines, angiogenic and anti-angiogenic factors. The RPE secretome, though crucial in health and disease, remains elusive in diabetic retinopathy. A knowledge of these secreted factors would help explain and correlate the clinical phase of the disease aiding in improved disease management. A comprehensive knowledge of the secreted factors of the RPE is a potential tool for understanding the differential treatment regime of early diabetic retinopathy, diabetic proliferative retinopathy and diabetic macular edema. In this review, we have delineated the importance of factors secreted by the retinal pigment epithelium and its regulation in the pathogenesis of diabetic retinopathy. (C) 2017 Elsevier Ltd. All rights reserved.

AB - Diabetic retinopathy is a major complication of diabetes mellitus that can lead to retinal vascular abnormalities and visual impairment. While retinal endothelial pathology is well studied, retinal pigment epithelium (RPE) layer modifications and the patho-physiological regulations are not widely understood. The RPE is a highly specialized pigmented layer regulating not only physiological functions such as transport of nutrients, ions, absorption of light, phagocytosis of photoreceptor membranes, but also secretion of a number of cytokines, chemokines, angiogenic and anti-angiogenic factors. The RPE secretome, though crucial in health and disease, remains elusive in diabetic retinopathy. A knowledge of these secreted factors would help explain and correlate the clinical phase of the disease aiding in improved disease management. A comprehensive knowledge of the secreted factors of the RPE is a potential tool for understanding the differential treatment regime of early diabetic retinopathy, diabetic proliferative retinopathy and diabetic macular edema. In this review, we have delineated the importance of factors secreted by the retinal pigment epithelium and its regulation in the pathogenesis of diabetic retinopathy. (C) 2017 Elsevier Ltd. All rights reserved.

KW - Retinal pigment epithelium

KW - Secretory factors

KW - Diabetic retinopathy

KW - VEGF

KW - Neovascularization

KW - Cytokines

KW - ENDOTHELIAL GROWTH-FACTOR

KW - MACULAR EDEMA

KW - GENE-EXPRESSION

KW - HIGH GLUCOSE

KW - ERYTHROPOIETIN PROTECTS

KW - OXIDATIVE STRESS

KW - INTERPHOTORECEPTOR MATRIX

KW - INTRAVITREAL BEVACIZUMAB

KW - BARRIER BREAKDOWN

KW - VISUAL FUNCTION

U2 - 10.1016/j.cyto.2017.02.013

DO - 10.1016/j.cyto.2017.02.013

M3 - (Systematic) Review article

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SN - 1043-4666

VL - 95

SP - 126

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JO - Cytokine

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