Retinal Microvasculature in Relation to Central Hemodynamics in a Flemish Population

Fang-Fei Wei*, Lutgarde Thijs, Cai-Guo Yu, Jesus D. Melgarejo, Zhen-Yu Zhang, Gladys E. Maestre, Harry A. J. Struijker-Boudier, Peter Verhamme, Jan A. Staessen

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

5 Citations (Web of Science)

Abstract

Arterial stiffness and wave reflection predict cardiovascular mortality and morbidity and are associated with renal microvascular disease. We hypothesized that the retinal microvascular traits might be associated with central hemodynamic properties. In 735 randomly recruited Flemish (mean age, 50.3 years; 47.1% women), we derived central pulse pressure and carotid-femoral pulse wave velocity by applanation tonometry and calculated forward (Pf) and backward (Pb) pulse waves, using an automated pressure-based wave separation algorithm. We measured central retinal arteriolar (CRAE) and venular equivalent and their ratio, using IVAN software (Vasculomatic ala Nicola, version 1.1). Mean values for pulse wave velocity (n=554), Pf and Pb were 7.50 m/s, 32.0 mm Hg, and 21.5 mm Hg, respectively. In multivariable-adjusted analyses, CRAE was 4.62 mu m and 1.26 mu m smaller (P

Original languageEnglish
Pages (from-to)606-613
Number of pages8
JournalHypertension
Volume74
Issue number3
DOIs
Publication statusPublished - Sep 2019

Keywords

  • arterial stiffness
  • blood pressure
  • hemodynamics
  • population
  • retina
  • PULSE-WAVE VELOCITY
  • ARTERIAL STIFFNESS
  • ATHEROSCLEROSIS RISK
  • AORTIC STIFFNESS
  • BLOOD-PRESSURE
  • VESSEL CALIBER
  • HEART-FAILURE
  • REFLECTION
  • MEN
  • ABNORMALITIES

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