Retinal Microvasculature in Relation to Central Hemodynamics in a Flemish Population

Fang-Fei Wei; Lutgarde Thijs; Cai-Guo Yu; Jesus D. Melgarejo; Zhen-Yu Zhang; Gladys E. Maestre; Harry A. J. Struijker-Boudier; Peter Verhamme; Jan A. Staessen

doi:10.1161/HYPERTENSIONAHA.119.13255

Retinal Microvasculature in Relation to Central Hemodynamics in a Flemish Population

Fang-Fei Wei^*, Lutgarde Thijs, Cai-Guo Yu, Jesus D. Melgarejo, Zhen-Yu Zhang, Gladys E. Maestre, Harry A. J. Struijker-Boudier, Peter Verhamme, Jan A. Staessen

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Arterial stiffness and wave reflection predict cardiovascular mortality and morbidity and are associated with renal microvascular disease. We hypothesized that the retinal microvascular traits might be associated with central hemodynamic properties. In 735 randomly recruited Flemish (mean age, 50.3 years; 47.1% women), we derived central pulse pressure and carotid-femoral pulse wave velocity by applanation tonometry and calculated forward (Pf) and backward (Pb) pulse waves, using an automated pressure-based wave separation algorithm. We measured central retinal arteriolar (CRAE) and venular equivalent and their ratio, using IVAN software (Vasculomatic ala Nicola, version 1.1). Mean values for pulse wave velocity (n=554), Pf and Pb were 7.50 m/s, 32.0 mm Hg, and 21.5 mm Hg, respectively. In multivariable-adjusted analyses, CRAE was 4.62 mu m and 1.26 mu m smaller (P

Original language	English
Pages (from-to)	606-613
Number of pages	8
Journal	Hypertension
Volume	74
Issue number	3
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.119.13255
Publication status	Published - Sept 2019

Keywords

ABNORMALITIES
AORTIC STIFFNESS
ARTERIAL STIFFNESS
ATHEROSCLEROSIS RISK
BLOOD-PRESSURE
HEART-FAILURE
MEN
PULSE-WAVE VELOCITY
REFLECTION
VESSEL CALIBER
arterial stiffness
blood pressure
hemodynamics
population
retina

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Cite this

@article{b62898a9c7d34247b1a345fc402be98f,

title = "Retinal Microvasculature in Relation to Central Hemodynamics in a Flemish Population",

abstract = "Arterial stiffness and wave reflection predict cardiovascular mortality and morbidity and are associated with renal microvascular disease. We hypothesized that the retinal microvascular traits might be associated with central hemodynamic properties. In 735 randomly recruited Flemish (mean age, 50.3 years; 47.1% women), we derived central pulse pressure and carotid-femoral pulse wave velocity by applanation tonometry and calculated forward (Pf) and backward (Pb) pulse waves, using an automated pressure-based wave separation algorithm. We measured central retinal arteriolar (CRAE) and venular equivalent and their ratio, using IVAN software (Vasculomatic ala Nicola, version 1.1). Mean values for pulse wave velocity (n=554), Pf and Pb were 7.50 m/s, 32.0 mm Hg, and 21.5 mm Hg, respectively. In multivariable-adjusted analyses, CRAE was 4.62 mu m and 1.26 mu m smaller (P",

keywords = "ABNORMALITIES, AORTIC STIFFNESS, ARTERIAL STIFFNESS, ATHEROSCLEROSIS RISK, BLOOD-PRESSURE, HEART-FAILURE, MEN, PULSE-WAVE VELOCITY, REFLECTION, VESSEL CALIBER, arterial stiffness, blood pressure, hemodynamics, population, retina",

author = "Fang-Fei Wei and Lutgarde Thijs and Cai-Guo Yu and Melgarejo, {Jesus D.} and Zhen-Yu Zhang and Maestre, {Gladys E.} and Struijker-Boudier, {Harry A. J.} and Peter Verhamme and Staessen, {Jan A.}",

note = "Funding Information: The European Union (HEALTH-F7-305507-HOMAGE), the European Research Council (Advanced Researcher Grant 2011-294713-EPLORE and Proof-of-Concept Grant 713601-uP-ROPHET), the European Research Area Net for Cardiovascular Diseases (JTC2017-046-PROACT), and the Research Foundation Flanders, Ministry of the Flemish Community, Brussels, Belgium (G.0881.13) supported the Studies Coordinating Centre in Leuven. Publisher Copyright: {\textcopyright} 2019 Lippincott Williams and Wilkins. All rights reserved.",

year = "2019",

month = sep,

doi = "10.1161/HYPERTENSIONAHA.119.13255",

language = "English",

volume = "74",

pages = "606--613",

journal = "Hypertension",

issn = "0194-911X",

publisher = "LIPPINCOTT WILLIAMS & WILKINS",

number = "3",

}

TY - JOUR

T1 - Retinal Microvasculature in Relation to Central Hemodynamics in a Flemish Population

AU - Wei, Fang-Fei

AU - Thijs, Lutgarde

AU - Yu, Cai-Guo

AU - Melgarejo, Jesus D.

AU - Zhang, Zhen-Yu

AU - Maestre, Gladys E.

AU - Struijker-Boudier, Harry A. J.

AU - Verhamme, Peter

AU - Staessen, Jan A.

N1 - Funding Information: The European Union (HEALTH-F7-305507-HOMAGE), the European Research Council (Advanced Researcher Grant 2011-294713-EPLORE and Proof-of-Concept Grant 713601-uP-ROPHET), the European Research Area Net for Cardiovascular Diseases (JTC2017-046-PROACT), and the Research Foundation Flanders, Ministry of the Flemish Community, Brussels, Belgium (G.0881.13) supported the Studies Coordinating Centre in Leuven. Publisher Copyright: © 2019 Lippincott Williams and Wilkins. All rights reserved.

PY - 2019/9

Y1 - 2019/9

N2 - Arterial stiffness and wave reflection predict cardiovascular mortality and morbidity and are associated with renal microvascular disease. We hypothesized that the retinal microvascular traits might be associated with central hemodynamic properties. In 735 randomly recruited Flemish (mean age, 50.3 years; 47.1% women), we derived central pulse pressure and carotid-femoral pulse wave velocity by applanation tonometry and calculated forward (Pf) and backward (Pb) pulse waves, using an automated pressure-based wave separation algorithm. We measured central retinal arteriolar (CRAE) and venular equivalent and their ratio, using IVAN software (Vasculomatic ala Nicola, version 1.1). Mean values for pulse wave velocity (n=554), Pf and Pb were 7.50 m/s, 32.0 mm Hg, and 21.5 mm Hg, respectively. In multivariable-adjusted analyses, CRAE was 4.62 mu m and 1.26 mu m smaller (P

AB - Arterial stiffness and wave reflection predict cardiovascular mortality and morbidity and are associated with renal microvascular disease. We hypothesized that the retinal microvascular traits might be associated with central hemodynamic properties. In 735 randomly recruited Flemish (mean age, 50.3 years; 47.1% women), we derived central pulse pressure and carotid-femoral pulse wave velocity by applanation tonometry and calculated forward (Pf) and backward (Pb) pulse waves, using an automated pressure-based wave separation algorithm. We measured central retinal arteriolar (CRAE) and venular equivalent and their ratio, using IVAN software (Vasculomatic ala Nicola, version 1.1). Mean values for pulse wave velocity (n=554), Pf and Pb were 7.50 m/s, 32.0 mm Hg, and 21.5 mm Hg, respectively. In multivariable-adjusted analyses, CRAE was 4.62 mu m and 1.26 mu m smaller (P

KW - ABNORMALITIES

KW - AORTIC STIFFNESS

KW - ARTERIAL STIFFNESS

KW - ATHEROSCLEROSIS RISK

KW - BLOOD-PRESSURE

KW - HEART-FAILURE

KW - MEN

KW - PULSE-WAVE VELOCITY

KW - REFLECTION

KW - VESSEL CALIBER

KW - arterial stiffness

KW - blood pressure

KW - hemodynamics

KW - population

KW - retina

U2 - 10.1161/HYPERTENSIONAHA.119.13255

DO - 10.1161/HYPERTENSIONAHA.119.13255

M3 - Article

C2 - 31280648

SN - 0194-911X

VL - 74

SP - 606

EP - 613

JO - Hypertension

JF - Hypertension

IS - 3

ER -