Resumption of Cardiac Activity after Withdrawal of Life-Sustaining Measures

S. Dhanani*, L. Hornby, A. van Beinum, N.B. Scales, M. Hogue, A. Baker, S. Beed, J.G. Boyd, J.A. Chandler, M. Chasse, F. D'Aragon, C. Dezfulian, C.J. Doig, F. Duska, J.O. Friedrich, D. Gardiner, T. Gofton, D. Harvey, C. Herry, G. IsacA.H. Kramer, D.J. Kutsogiannis, D.M. Maslove, M. Meade, S. Mehta, L. Munshi, L. Norton, G. Pagliarello, T. Ramsay, K. Rusinova, D. Scales, M. Schmidt, A. Seely, J. Shahin, M. Slessarev, D. So, H. Talbot, W.N.K.A. van Mook, P. Waldauf, M. Weiss, J.T. Wind, S.D. Shemie, Canadian Critical Care Trials Group, Canadian Donation and Transplantation Research Program

*Corresponding author for this work

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BACKGROUNDThe minimum duration of pulselessness required before organ donation after circulatory determination of death has not been well studied.METHODSWe conducted a prospective observational study of the incidence and timing of resumption of cardiac electrical and pulsatile activity in adults who died after planned withdrawal of life-sustaining measures in 20 intensive care units in three countries. Patients were intended to be monitored for 30 minutes after determination of death. Clinicians at the bedside reported resumption of cardiac activity prospectively. Continuous blood-pressure and electrocardiographic (ECG) wave-forms were recorded and reviewed retrospectively to confirm bedside observations and to determine whether there were additional instances of resumption of cardiac activity.RESULTSA total of 1999 patients were screened, and 631 were included in the study. Clinically reported resumption of cardiac activity, respiratory movement, or both that was confirmed by waveform analysis occurred in 5 patients (1%). Retrospective analysis of ECG and blood-pressure waveforms from 480 patients identified 67 instances (14%) with resumption of cardiac activity after a period of pulselessness, including the 5 reported by bedside clinicians. The longest duration after pulselessness before resumption of cardiac activity was 4 minutes 20 seconds. The last QRS complex coincided with the last arterial pulse in 19% of the patients.CONCLUSIONSAfter withdrawal of life-sustaining measures, transient resumption of at least one cycle of cardiac activity after pulselessness occurred in 14% of patients according to retrospective analysis of waveforms; only 1% of such resumptions were identified at the bedside. These events occurred within 4 minutes 20 seconds after a period of pulselessness. (Funded by the Canadian Institutes for Health Research and others.)
Original languageEnglish
Pages (from-to)345-352
Number of pages8
JournalNew England Journal of Medicine
Issue number4
Publication statusPublished - 28 Jan 2021


  • autoresuscitation
  • death
  • donation
  • transplantation

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