TY - JOUR
T1 - Resting-state fMRI in Parkinson's disease patients with cognitive impairment
T2 - A meta-analysis
AU - Wolters, Amee F.
AU - van de Weijer, Sjors C. F.
AU - Leentjens, Albert F. G.
AU - Duits, Annelien A.
AU - Jacobs, Heidi I. L.
AU - Kuijf, Mark L.
N1 - Funding Information:
This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.AW: Nothing to declare. SW: Nothing to declare. HJ: Heidi Jacobs is supported by funding from NWO ( Veni – [451-14-035] ), Alzheimer Nederland (fellowship [ WE.15-2014-06 ]), a standard grant of the Internationale Stichting Alzheimer Onderzoek [ #15007 ] and a research grant by the Deutsche Forschungsgemeinschaft [ JA/2336/1-1 ]. AL: A.F.G. Leentjens received research grants from the Michael J. Fox Foundation , as well as royalties from Reed-Elsevier, de Tijdstroom and Van Gorcum publishers. He receives payment from Elsevier Inc as Editor-in-Chief of the Journal of Psychsomatic Research. AD: A.A. Duits receives royalties from Hogrefe publishers. MK: Nothing to declare.
Publisher Copyright:
© 2018 Elsevier Ltd
PY - 2019/5
Y1 - 2019/5
N2 - Background. Cognitive impairment is a common non-motor symptom in Parkinson's disease. So far, the underlying pathophysiology remains unclear. Several alterations in functional network connectivity have been described in Parkinson's disease patients with cognitive impairment which are probably the result of the heterogenous pathophysiology underlying this cognitive decline, including dopaminergic and cholinergic deficits. Accordingly, the reported resting-state connectivity patterns vary greatly among studies.Objective: To evaluate the localization and magnitude of functional connectivity patterns in resting-state brain networks in Parkinson's disease patients with cognitive impairment by pooling data from available studies.Methods: We searched PubMed, the Cochrane Library, MEDLINE, Embase and PsycINFO to identify functional MRI studies in Parkinson's disease patients with cognitive impairment. A voxel-based meta-analysis combined with quality statistics was performed, using the anisotropic effect-size version of the signed differential mapping method.Results: Seventeen studies with cognitively impaired Parkinson's disease patients were included consisting of 222 Parkinson's disease patients with mild cognitive impairment, 68 patients with Parkinson's disease dementia, 289 cognitively unimpaired Parkinson's disease patients and 353 healthy controls. Parkinson's disease patients with cognitive impairment predominantly showed a reduced connectivity in specific brain regions that are part of the default mode network.Conclusion: Cognitive impairment in Parkinson's disease is associated with reduced connectivity in networks relevant to cognition, most prominently the default mode network. Specific alterations in functional connectivity may contribute to cognitive decline in Parkinson patients and may be a promising future biomarker.
AB - Background. Cognitive impairment is a common non-motor symptom in Parkinson's disease. So far, the underlying pathophysiology remains unclear. Several alterations in functional network connectivity have been described in Parkinson's disease patients with cognitive impairment which are probably the result of the heterogenous pathophysiology underlying this cognitive decline, including dopaminergic and cholinergic deficits. Accordingly, the reported resting-state connectivity patterns vary greatly among studies.Objective: To evaluate the localization and magnitude of functional connectivity patterns in resting-state brain networks in Parkinson's disease patients with cognitive impairment by pooling data from available studies.Methods: We searched PubMed, the Cochrane Library, MEDLINE, Embase and PsycINFO to identify functional MRI studies in Parkinson's disease patients with cognitive impairment. A voxel-based meta-analysis combined with quality statistics was performed, using the anisotropic effect-size version of the signed differential mapping method.Results: Seventeen studies with cognitively impaired Parkinson's disease patients were included consisting of 222 Parkinson's disease patients with mild cognitive impairment, 68 patients with Parkinson's disease dementia, 289 cognitively unimpaired Parkinson's disease patients and 353 healthy controls. Parkinson's disease patients with cognitive impairment predominantly showed a reduced connectivity in specific brain regions that are part of the default mode network.Conclusion: Cognitive impairment in Parkinson's disease is associated with reduced connectivity in networks relevant to cognition, most prominently the default mode network. Specific alterations in functional connectivity may contribute to cognitive decline in Parkinson patients and may be a promising future biomarker.
KW - Parkinson's disease
KW - Functional MRI
KW - Cognitive impairment
KW - Functional connectivity
KW - Resting-state network
KW - DEFAULT-MODE NETWORK
KW - CLINICAL DIAGNOSTIC-CRITERIA
KW - FUNCTIONAL BRAIN NETWORKS
KW - VOXEL-WISE METAANALYSIS
KW - ALZHEIMERS-DISEASE
KW - LOCUS-COERULEUS
KW - LEWY BODIES
KW - GRAY-MATTER
KW - CONNECTIVITY
KW - DEMENTIA
U2 - 10.1016/j.parkreldis.2018.12.016
DO - 10.1016/j.parkreldis.2018.12.016
M3 - (Systematic) Review article
C2 - 30580907
SN - 1353-8020
VL - 62
SP - 16
EP - 27
JO - Parkinsonism & Related Disorders
JF - Parkinsonism & Related Disorders
ER -