Response of platelet concentrates to pressure and temperature changes without impairment of the in vitro function

Cecile Kicken, Sven Van Poucke*, Abraham Emanuel Marcus, Marcus D. Lance, Yvonne Henskens

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

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Background: Rapid platelet concentrate (PC) transfusion is crucial for hemostatic resuscitation. Pressure-aided and warmed transfusion combined with pneumatic tube system (PTS) transport from the laboratory to the operating theatre offers a potentially rapid delivery technique. The aim of this study is a quantitative assessment of in vitro platelet function after PTS transport followed by warmed and/or pressure-aided mock transfusions. Methods: Ten PC samples entered a single PTS run and were subsequently aliquoted for testing. PCs were warmed in a blood warmer and/or subjected to pressure-aided mock transfusion at 300 mm Hg on day 2 or day 7 after collection. Platelet function was assessed using light-transmission aggregometry and multiple-electrode aggregometry to measure the response to ADP, arachidonic acid, collagen, and thrombin-receptor activating peptide. Data were analyzed with non-parametric testing; P <0.05 was considered statistically significant. Results: Single PTS transport markedly reduced ADP response in fresh PCs. Seven-day storage had a pronounced effect on both ADP and collagen response. All other tested platelet agonists revealed preserved function. Subsequent warming and/or application of pressure did not significantly compromise platelet function. Conclusions: Pressure-aided plus warmed transfusion and PTS transport was not found to be detrimental to the PC. Further clinical studies are required to determine safety and efficacy of the product.
Original languageEnglish
Pages (from-to)679-683
JournalThrombosis Research
Issue number4
Publication statusPublished - Apr 2015


  • Platelets
  • Aggregometry
  • Transfusion
  • Pneumatic tube system

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