Respiratory sensitization: Advances in assessing the risk of respiratory inflammation and irritation

Rob J. Vandebriel*, Conchita Callant Cransveld, Daan Crommelin, Zuzana Diamant, Berend Glazenburg, Guy Joos, Frieke C. Kuper, Andreas Natsch, Frans Nijkamp, Hub Noteborn, Raymond Pieters, David Roberts, Erwin Roggen, Emiel Rorije, Martin Seed, Katharina Sewald, Rosette van den Heuvel, Jacqueline van Engelen, Sandra Verstraelen, Henk van Loveren

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

11 Citations (Web of Science)

Abstract

Respiratory sensitization provides a case study for a new approach to chemical safety evaluation, as the prevalence of respiratory sensitization has increased considerably over the last decades, but animal and/or human experimental/predictive models are not currently available. Therefore, the goal of a working group was to design a road map to develop an ASAT approach for respiratory sensitisers. This approach should aim at (i) creating a database on respiratory functional biology and toxicology, (ii) applying data analyses to understand the multi-dimensional sensitization response, and how this predisposes to respiratory inflammation and irritation, and (iii) building a systems model out of these analyses, adding pharmacokinetic-pharmacodynamic modeling to predict respiratory responses to low levels of sensitisers. To this end, the best way forward would be to follow an integrated testing approach. Experimental research should be targeted to (i) QSAR-type approaches to relate potential as a respiratory sensitizer to its chemical structure, (ii) in vitro models and (iii) in vitro-in vivo extrapolation/validation.
Original languageEnglish
Pages (from-to)1251-1258
JournalToxicology in Vitro
Volume25
Issue number7
DOIs
Publication statusPublished - Oct 2011

Keywords

  • ASAT
  • Respiratory tract
  • Sensitization
  • Rhinitis
  • Asthma
  • Integrated testing
  • Risk assessment
  • QSAR
  • In vitro
  • In vivo

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