Resistance to annexin A5 anticoagulant activity in women with histories for obstetric antiphospholipid syndrome

Beverley J. Hunt*, Xiao-Xuan Wu, Bas de Laat, Alan A. Arslan, Sara Stuart-Smith, Jacob H. Rand

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

17 Citations (Web of Science)

Abstract

The objective of the study was to investigate whether resistance to annexin A5 anticoagulant activity (AnxA5) occurs in women with histories for obstetric complications of antiphospholipid syndrome (Obs-APS) and whether this correlates with antibody recognition of domain 1 of ?2-glycoprotein.One hundred thirty-six women with antiphospholipid antibodies, including 70 with histories for Obs-APS and 30 controls, were investigated.Women with Obs-APS showed resistance to AnxA5 activity (median, 216%; range, 130-282% vs controls; median, 247%; range, 217-283%; P <.0001) and elevated levels of anti-domain I immunoglobulin (Ig) G (optical density: median, 0.056; range, 0.021-0.489 vs median, 0.042; range, 0.020-0.323; P = .002). Those in the lowest tertile of AnxA5 anticoagulant ratios had an odds ratio for Obs-APS of 58.0 (95% confidence interval, 3.3-1021.5). There was an inverse correlation between levels of annexin A5 anticoagulant activity and anti-domain I IgG.Resistance to AnxA5 anticoagulant activity is associated with antibody recognition of domain I of ?2-glycoprotein I and identifies a subset of women with histories for Obs-APS.
Original languageEnglish
JournalAmerican Journal of Obstetrics and Gynecology
Volume205
Issue number5
DOIs
Publication statusPublished - Nov 2011

Keywords

  • annexin A5
  • antiphospholipid antibodies
  • antiphospholipid syndrome
  • obstetric
  • beta 2-glycoprotein I
  • pregnancy loss

Cite this