Residual effects on actual car driving of evening doses of chlorpheniramine 8 and 12 mg when used with terfenadine 60mg in the morning.

A. Vermeeren, J.G. Ramaekers, C.J. van Leeuwen, J.F. O'Hanlon

    Research output: Contribution to journalArticleAcademicpeer-review

    Abstract

    The study was conducted according to a 4-way, observer- and subject-blind, cross-over design. Its purpose was to compare the repeated dose effects on actual driving performance of the following: the combination of chlorpheniramine 8 and 12 mg, in sustained release formulations, administered at bedtime and terfenadine 60 mg the following morning; flurazepam 30 mg at bedtime and placebo the following morning; and, placebo at both times. Subjects were 24 healthy female volunteers. Drug effects were assessed in two driving tests (highway driving and car-following) in the morning of the third treatment day. Results show no significant differences in driving performance between both chlorpheniramine/terfenadine treatments and placebo. Flurazepam significantly impaired driving in both tests.
    Original languageEnglish
    Pages (from-to)S79-S86
    JournalHuman Psychopharmacology-Clinical and Experimental
    Volume13
    Issue numberS2
    DOIs
    Publication statusPublished - 1 Jan 1998

    Cite this

    @article{39662907a3394ef6974c4158a92dc354,
    title = "Residual effects on actual car driving of evening doses of chlorpheniramine 8 and 12 mg when used with terfenadine 60mg in the morning.",
    abstract = "The study was conducted according to a 4-way, observer- and subject-blind, cross-over design. Its purpose was to compare the repeated dose effects on actual driving performance of the following: the combination of chlorpheniramine 8 and 12 mg, in sustained release formulations, administered at bedtime and terfenadine 60 mg the following morning; flurazepam 30 mg at bedtime and placebo the following morning; and, placebo at both times. Subjects were 24 healthy female volunteers. Drug effects were assessed in two driving tests (highway driving and car-following) in the morning of the third treatment day. Results show no significant differences in driving performance between both chlorpheniramine/terfenadine treatments and placebo. Flurazepam significantly impaired driving in both tests.",
    author = "A. Vermeeren and J.G. Ramaekers and {van Leeuwen}, C.J. and J.F. O'Hanlon",
    year = "1998",
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    Residual effects on actual car driving of evening doses of chlorpheniramine 8 and 12 mg when used with terfenadine 60mg in the morning. / Vermeeren, A.; Ramaekers, J.G.; van Leeuwen, C.J.; O'Hanlon, J.F.

    In: Human Psychopharmacology-Clinical and Experimental, Vol. 13, No. S2, 01.01.1998, p. S79-S86.

    Research output: Contribution to journalArticleAcademicpeer-review

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    T1 - Residual effects on actual car driving of evening doses of chlorpheniramine 8 and 12 mg when used with terfenadine 60mg in the morning.

    AU - Vermeeren, A.

    AU - Ramaekers, J.G.

    AU - van Leeuwen, C.J.

    AU - O'Hanlon, J.F.

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    AB - The study was conducted according to a 4-way, observer- and subject-blind, cross-over design. Its purpose was to compare the repeated dose effects on actual driving performance of the following: the combination of chlorpheniramine 8 and 12 mg, in sustained release formulations, administered at bedtime and terfenadine 60 mg the following morning; flurazepam 30 mg at bedtime and placebo the following morning; and, placebo at both times. Subjects were 24 healthy female volunteers. Drug effects were assessed in two driving tests (highway driving and car-following) in the morning of the third treatment day. Results show no significant differences in driving performance between both chlorpheniramine/terfenadine treatments and placebo. Flurazepam significantly impaired driving in both tests.

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