@article{4823f940ac90420faa1b26a3181eb1df,
title = "Reshaping Lipid Biochemistry by Pushing Barriers in Structural Lipidomics",
abstract = "Lipidomics is a rapidly growing field with numerous examples showing the importance of lipid molecules throughout biology. It has also shed light onto the vast and complex functions performed by many lipids that possess an immense diversity in molecular structures. Mass spectrometry (MS) is the tool of choice for analyzing lipids and has been the key catalyst driving the field forward. However, MS does not yet permit true molecular lipidomics wherein the identification and quantification of lipids having defined molecular structures can be routinely achieved. Here we describe recent advances in MS-based lipidomics that allow access to higher levels of molecular information in lipidomics experiments. These advances will form a key piece of the puzzle as the field moves towards systems characterization of lipids at the molecular level.",
keywords = "biochemistry, isomers, lipidomics, mass spectrometry, structural identification, OZONE-INDUCED DISSOCIATION, NM ULTRAVIOLET PHOTODISSOCIATION, MOBILITY-MASS-SPECTROMETRY, DOUBLE-BOND POSITION, ACYL-CHAIN POSITION, ELECTROSPRAY-IONIZATION, LIQUID-CHROMATOGRAPHY, QUANTITATIVE-ANALYSIS, SHOTGUN LIPIDOMICS, MEMBRANE-LIPIDS",
author = "Siegel, {Tiffany Porta} and Kim Ekroos and Ellis, {Shane R.}",
note = "Funding Information: This work was supported by the Dutch Province of Limburg through the LINK program. S.R.E. acknowledges funding from InterregV-EMR and the Netherlands Ministry of Economic Affairs within the “EURLIPIDS” project (project number EMR23). We are grateful to Prof. Jennifer Brodbelt (University of Texas at Austin, USA), Prof. Yu Xia (Tsinghua University, China), and Dr. Berwyck Poad/Prof. Stephen Blanksby (Queensland University of Technology, Australia) for providing the raw data used to prepare Figure 2. Funding Information: This work was supported by the Dutch Province of Limburg through the LINK program. S.R.E. acknowledges funding from InterregV-EMR and the Netherlands Ministry of Economic Affairs within the ?EURLIPIDS? project (project number EMR23). We are grateful to Prof. Jennifer Brodbelt (University of Texas at Austin, USA), Prof. Yu Xia (Tsinghua University, China), and Dr. Berwyck Poad/Prof. Stephen Blanksby (Queensland University of Technology, Australia) for providing the raw data used to prepare Figure. Publisher Copyright: {\textcopyright} 2019 The Authors. Published by Wiley-VCH Verlag GmbH & Co. KGaA.",
year = "2019",
month = may,
day = "13",
doi = "10.1002/anie.201812698",
language = "English",
volume = "58",
pages = "6492--6501",
journal = "Angewandte Chemie-International Edition",
issn = "1433-7851",
publisher = "John Wiley & Sons Inc.",
number = "20",
}