Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis-Addicted Breast Tumor Growth

S.L. Geeraerts, K.R. Kampen, G. Rinaldi, P. Gupta, M. Planque, N. Louros, E. Heylen, K. De Cremer, K. De Brucker, S. Vereecke, B. Verbelen, P. Vermeersch, J. Schymkowitz, F. Rousseau, D. Cassiman, S.M. Fendt, A. Voet, B.P.A. Cammue, K. Thevissen*, K. De Keersmaecker*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

9 Citations (Web of Science)
Original languageEnglish
Pages (from-to)50-63
Number of pages14
JournalMolecular Cancer Therapeutics
Volume20
Issue number1
DOIs
Publication statusPublished - 1 Jan 2021

Keywords

  • artemisinins
  • biosynthesis pathway
  • cancer
  • dehydrogenase
  • expression
  • glycine
  • identification
  • metabolism
  • mitochondrial serine hydroxymethyltransferase
  • one-carbon unit
  • ARTEMISININS
  • GLYCINE
  • MITOCHONDRIAL SERINE HYDROXYMETHYLTRANSFERASE
  • IDENTIFICATION
  • CANCER
  • ONE-CARBON UNIT
  • DEHYDROGENASE
  • BIOSYNTHESIS PATHWAY
  • METABOLISM
  • EXPRESSION

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