Reproducibility of dynamic cerebral autoregulation parameters: a multi-centre, multi-method study

Marit L. Sanders, Jurgen A. H. R. Claassen*, Marcel Aries, Edson Bor-Seng-Shu, Alexander Caicedo, Max Chacon, Erik D. Gommer, Sabine Van Huffel, Jose L. Jara, Kyriaki Kostoglou, Adam Mahdi, Vasilis Z. Marmarelis, Georgios D. Mitsis, Martin Muller, Dragan A. Nikolic, Ricardo C. Nogueira, Stephen J. Payne, Corina Puppo, Dae C. Shin, David M. SimpsonTakashi Tarumi, Bernardo Yelicichs, Rong Zhang, Ronney B. Panerai, Jan Willem J. Elting

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

22 Citations (Web of Science)
4 Downloads (Pure)


Objective: Different methods to calculate dynamic cerebral autoregulation (dCA) parameters are available. However, most of these methods demonstrate poor reproducibility that limit their reliability for clinical use. Inter-centre differences in study protocols, modelling approaches and default parameter settings have all led to a lack of standardisation and comparability between studies. We evaluated reproducibility of dCA parameters by assessing systematic errors in surrogate data resulting from different modelling techniques. Approach: Fourteen centres analysed 22 datasets consisting of two repeated physiological blood pressure measurements with surrogate cerebral blood flow velocity signals, generated using Tiecks curves (autoregulation index, ARI 0-9) and added noise. For reproducibility, dCA methods were grouped in three broad categories: 1. Transfer function analysis (TFA)-like output; 2. ARI-like output; 3. Correlation coefficient-like output. For all methods, reproducibility was determined by one-way intraclass correlation coefficient analysis (ICC). Main results: For TFA-like methods the mean (SD; [range]) ICC gain was 0.71 (0.10; [0.49-0.86]) and 0.80 (0.17; [0.36-0.94]) for VLF and LF (p = 0.003) respectively. For phase, ICC values were 0.53 (0.21; [0.09-0.80]) for VLF, and 0.92 (0.13; [0.44-1.00]) for LF (p <0.001). Finally, ICC for ARI-like methods was equal to 0.84 (0.19; [0.41-0.94]), and for correlation-like methods, ICC was 0.21 (0.21; [0.056-0.35]). Significance: When applied to realistic surrogate data, free from the additional exogenous influences of physiological variability on cerebral blood flow, most methods of dCA modelling showed ICC values considerably higher than what has been reported for physiological data. This finding suggests that the poor reproducibility reported by previous studies may be mainly due to the inherent physiological variability of cerebral blood flow regulatory mechanisms rather than related to (stationary) random noise and the signal analysis methods.

Original languageEnglish
Article number125002
Pages (from-to)1-13
Number of pages13
JournalPhysiological Measurement
Issue number12
Publication statusPublished - Dec 2018


  • cerebral autoregulation
  • method comparison
  • reproducibility
  • surrogate data
  • FLOW

Cite this