Abstract
Background Women have traditionally been underrepresented in randomized clinical trials (RCTs). We performed a systematic evaluation of the inclusion of women in cardiac surgery RCTs published in the past 2 decades. Methods and Results MEDLINE, EMBASE, and the Cochrane Library were searched (2000 to July 2020) for RCTs written in English, comparing >= 2 adult cardiac surgical procedures. The percentage of women enrolled and its association with year of publication, sample size, mean age, funding source, geographic location, number of sites involved, and interventions tested were analyzed using a meta-analytic approach. Fifty-one trials were included. Of 25 425 total patients, 5029 were women (20.8%; 95% CI, 17.6-24.4; range, 0.5%-57.9%). The proportion of women dropped significantly during the study period (29.6% in 2000 versus 13.1% in 2019, P
Original language | English |
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Article number | 020513 |
Number of pages | 20 |
Journal | Journal of the American Heart Association |
Volume | 10 |
Issue number | 16 |
DOIs | |
Publication status | Published - 17 Aug 2021 |
Keywords
- cardiac surgery
- RCT
- women
- ARTERY-BYPASS SURGERY
- INTERNAL-THORACIC-ARTERY
- OF-LIFE OUTCOMES
- ON-PUMP SURGERY
- RADIAL-ARTERY
- SAPHENOUS-VEIN
- CORONARY SURGERY
- MYOCARDIAL REVASCULARIZATION
- VALVE SURGERY
- GRAFT PATENCY