Representation of Women in Randomized Trials in Cardiac Surgery: A Meta-Analysis

Mario Gaudino; Michele Di Mauro; Stephen E. Fremes; Antonino Di Franco

doi:10.1161/jaha.120.020513

Representation of Women in Randomized Trials in Cardiac Surgery: A Meta-Analysis

Mario Gaudino^*, Michele Di Mauro, Stephen E. Fremes, Antonino Di Franco

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

1 Citation (Web of Science)

Abstract

Background Women have traditionally been underrepresented in randomized clinical trials (RCTs). We performed a systematic evaluation of the inclusion of women in cardiac surgery RCTs published in the past 2 decades. Methods and Results MEDLINE, EMBASE, and the Cochrane Library were searched (2000 to July 2020) for RCTs written in English, comparing >= 2 adult cardiac surgical procedures. The percentage of women enrolled and its association with year of publication, sample size, mean age, funding source, geographic location, number of sites involved, and interventions tested were analyzed using a meta-analytic approach. Fifty-one trials were included. Of 25 425 total patients, 5029 were women (20.8%; 95% CI, 17.6-24.4; range, 0.5%-57.9%). The proportion of women dropped significantly during the study period (29.6% in 2000 versus 13.1% in 2019, P

Original language	English
Article number	020513
Number of pages	20
Journal	Journal of the American Heart Association
Volume	10
Issue number	16
DOIs	https://doi.org/10.1161/jaha.120.020513
Publication status	Published - 17 Aug 2021

Keywords

cardiac surgery
RCT
women
ARTERY-BYPASS SURGERY
INTERNAL-THORACIC-ARTERY
OF-LIFE OUTCOMES
ON-PUMP SURGERY
RADIAL-ARTERY
SAPHENOUS-VEIN
CORONARY SURGERY
MYOCARDIAL REVASCULARIZATION
VALVE SURGERY
GRAFT PATENCY

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10.1161/jaha.120.020513

Cite this

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title = "Representation of Women in Randomized Trials in Cardiac Surgery: A Meta-Analysis",

abstract = "Background Women have traditionally been underrepresented in randomized clinical trials (RCTs). We performed a systematic evaluation of the inclusion of women in cardiac surgery RCTs published in the past 2 decades. Methods and Results MEDLINE, EMBASE, and the Cochrane Library were searched (2000 to July 2020) for RCTs written in English, comparing >= 2 adult cardiac surgical procedures. The percentage of women enrolled and its association with year of publication, sample size, mean age, funding source, geographic location, number of sites involved, and interventions tested were analyzed using a meta-analytic approach. Fifty-one trials were included. Of 25 425 total patients, 5029 were women (20.8%; 95% CI, 17.6-24.4; range, 0.5%-57.9%). The proportion of women dropped significantly during the study period (29.6% in 2000 versus 13.1% in 2019, P",

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author = "Mario Gaudino and {Di Mauro}, Michele and Fremes, {Stephen E.} and {Di Franco}, Antonino",

year = "2021",

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T2 - A Meta-Analysis

AU - Gaudino, Mario

AU - Di Mauro, Michele

AU - Fremes, Stephen E.

AU - Di Franco, Antonino

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AB - Background Women have traditionally been underrepresented in randomized clinical trials (RCTs). We performed a systematic evaluation of the inclusion of women in cardiac surgery RCTs published in the past 2 decades. Methods and Results MEDLINE, EMBASE, and the Cochrane Library were searched (2000 to July 2020) for RCTs written in English, comparing >= 2 adult cardiac surgical procedures. The percentage of women enrolled and its association with year of publication, sample size, mean age, funding source, geographic location, number of sites involved, and interventions tested were analyzed using a meta-analytic approach. Fifty-one trials were included. Of 25 425 total patients, 5029 were women (20.8%; 95% CI, 17.6-24.4; range, 0.5%-57.9%). The proportion of women dropped significantly during the study period (29.6% in 2000 versus 13.1% in 2019, P

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KW - RADIAL-ARTERY

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KW - GRAFT PATENCY

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