TY - JOUR
T1 - Report of the first international consensus on standardized nomenclature of antinuclear antibody HEp-2 cell patterns 2014-2015
AU - Chan, Edward K. L.
AU - Damoiseaux, Jan
AU - Gabriel Carballo, Orlando
AU - Conrad, Karsten
AU - Cruvinel, Wilson de Melo
AU - Carvalho Francescantonio, Paulo Luiz
AU - Fritzler, Marvin J.
AU - Garcia-De La Torre, Ignacio
AU - Herold, Manfred
AU - Mimori, Tsuneyo
AU - Satoh, Minoru
AU - von Muehlen, Carlos A.
AU - Andrade, Luis E. C.
PY - 2015/8/20
Y1 - 2015/8/20
N2 - During the 12th International Workshop on Autoantibodies and Autoimmunity held in Sao Paulo, Brazil, on August 28, 2014, a full day session was devoted to establishing a consensus on the nomenclature of staining patterns observed in the antinuclear antibody (ANA) indirect immunofluorescence test on HEp-2 cells. The current report summarizes the collective agreements with input from the host Brazilian and international communities that represented research, clinical, and diagnostic service laboratories. Patterns are categorized in three major groups (nuclear, cytoplasmic, and mitotic patterns) and each pattern has been defined and described in detail. The consensus nomenclature and representative patterns are made available online at the international consensus on antinuclear antibody pattern (ICAP) website (www.ANApatterns.org). To facilitate continuous improvement and input, specific comments on ICAP are encouraged and these will be discussed in subsequent ICAP meetings. The ultimate goal with the establishment of the ICAP is to promote harmonization and understanding of autoantibody test nomenclature, as well as interpretation guidelines for ANA testing, thereby optimizing usage in patient care.
AB - During the 12th International Workshop on Autoantibodies and Autoimmunity held in Sao Paulo, Brazil, on August 28, 2014, a full day session was devoted to establishing a consensus on the nomenclature of staining patterns observed in the antinuclear antibody (ANA) indirect immunofluorescence test on HEp-2 cells. The current report summarizes the collective agreements with input from the host Brazilian and international communities that represented research, clinical, and diagnostic service laboratories. Patterns are categorized in three major groups (nuclear, cytoplasmic, and mitotic patterns) and each pattern has been defined and described in detail. The consensus nomenclature and representative patterns are made available online at the international consensus on antinuclear antibody pattern (ICAP) website (www.ANApatterns.org). To facilitate continuous improvement and input, specific comments on ICAP are encouraged and these will be discussed in subsequent ICAP meetings. The ultimate goal with the establishment of the ICAP is to promote harmonization and understanding of autoantibody test nomenclature, as well as interpretation guidelines for ANA testing, thereby optimizing usage in patient care.
KW - antinuclear antibodies
KW - autoantibody
KW - autoimmunity
KW - consensus
KW - standardization
U2 - 10.3389/fimmu.2015.00412
DO - 10.3389/fimmu.2015.00412
M3 - Article
C2 - 26347739
VL - 6
JO - Frontiers in Immunology
JF - Frontiers in Immunology
SN - 1664-3224
M1 - 412
ER -