Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene-environment interaction. The EUGEI study

Jim van Os*, Lotta-Katrin Pries, Philippe Delespaul, Gunter Kenis, Jurjen J Luykx, Bochao D Lin, Alexander L Richards, Berna Akdede, Tolga Binbay, Vesile Altınyazar, Berna Yalınçetin, Güvem Gümüş-Akay, Burçin Cihan, Haldun Soygür, Halis Ulaş, Eylem Şahin Cankurtaran, Semra Ulusoy Kaymak, Marina M Mihaljevic, Sanja Andric Petrovic, Tijana MirjanicMiguel Bernardo, Bibiana Cabrera, Julio Bobes, Pilar A Saiz, María Paz García-Portilla, Julio Sanjuan, Eduardo J Aguilar, José Luis Santos, Estela Jiménez-López, Manuel Arrojo, Angel Carracedo, Gonzalo López, Javier González-Peñas, Mara Parellada, Nadja P Maric, Cem Atbaşoğlu, Alp Ucok, Köksal Alptekin, Meram Can Saka, Celso Arango, Michael O'Donovan, Bart P F Rutten, Sinan Guloksuz, Genetic Risk and Outcome of Psychosis (GROUP) Investigators

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Original languageEnglish
Article number003329171900196
Pages (from-to)1884-1897
Number of pages14
JournalPsychological Medicine
Volume50
Issue number11
Early online date15 Aug 2019
DOIs
Publication statusPublished - Aug 2020

Keywords

  • Cognition
  • genetics
  • schizophrenia
  • schizotypy
  • STRUCTURED INTERVIEW
  • RELIABILITY
  • PSYCHOSIS
  • ASSOCIATION
  • DISORDERS
  • CHILDHOOD
  • LIABILITY
  • VALIDITY
  • OVERLAP
  • HISTORY

Cite this

van Os, J., Pries, L-K., Delespaul, P., Kenis, G., Luykx, J. J., Lin, B. D., Richards, A. L., Akdede, B., Binbay, T., Altınyazar, V., Yalınçetin, B., Gümüş-Akay, G., Cihan, B., Soygür, H., Ulaş, H., Cankurtaran, E. Ş., Kaymak, S. U., Mihaljevic, M. M., Petrovic, S. A., ... Genetic Risk and Outcome of Psychosis (GROUP) Investigators (2020). Replicated evidence that endophenotypic expression of schizophrenia polygenic risk is greater in healthy siblings of patients compared to controls, suggesting gene-environment interaction. The EUGEI study. Psychological Medicine, 50(11), 1884-1897. [003329171900196]. https://doi.org/10.1017/S003329171900196X