Repetitive Intrathecal VEGF(165) Treatment Has Limited Therapeutic Effects after Spinal Cord Injury in the Rat

Sabien van Neerven, Elbert A. J. Joosten, Gary A. Brook, Charles A. Lambert, Joerg Mey, Joachim Weis, Marco A. Marcus, Harry W. Steinbusch, Maarten van Kleef, Jaap Patijn, Ronald Deumens*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

15 Citations (Web of Science)

Abstract

Neuropathic pain and motor deficits are detrimental consequences of injury to the spinal cord. In experimental settings, numerous neuroprotective agents are being explored for their therapeutic benefits. Vascular endothelial growth factor (VEGF) is an interesting candidate molecule in this respect since it is not only associated with angiogenesis, but also with neuroprotection and neurite growth. Other investigators have reported improved motor outcomes following intraparenchymal VEGF treatment. Here we demonstrate the therapeutic effects of daily intrathecal treatment of the contused thoracic rat spinal cord with the 165-isoform of VEGF during the first week after injury. We show that VEGF treatment resulted in a statistically significant attenuation of mechanical, but not thermal, hypersensitivity of the hindpaws, while motor deficits remained unaffected. Tissue sparing was also unchanged by VEGF treatment. Microglial responses at the lumbar spinal cord, which have been linked with spinal cord injury-induced hypersensitivity, were found to be unaffected by VEGF treatment. We conclude that repetitive intrathecal VEGF delivery has limited therapeutic effects on spinal cord injury outcome.
Original languageEnglish
Pages (from-to)1781-1791
JournalJournal of Neurotrauma
Volume27
Issue number10
DOIs
Publication statusPublished - Oct 2010

Keywords

  • central pain
  • glia
  • neuroplasticity
  • neuroprotection

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