Repeat breast-conserving therapy for ipsilateral breast cancer recurrence: A systematic review

Coco J. E. F. Walstra*, Robert-Jan Schipper, Ingrid G. M. Poodt, Yvonne E. van Riet, Adri C. Voogd, Maurice J. C. van der Sangen, Grard A. P. Nieuwenhuijzen

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Citations (Web of Science)

Abstract

The standard of care for patients with an ipsilateral breast tumour recurrence (IBTR) after breast-conserving therapy (BCT) is a salvage mastectomy. However, there is growing interest in the feasibility of repeat BCT for these patients. This systematic review contains the latest insights on BCT options for patients with an IBTR after initial BCT.

A PubMed literature search was performed for articles on BCT options for IBTR after primary lumpectomy followed by radiotherapy. Weighted estimates were calculated for 5- and 10-year local control, distant metastasis-free and overall survival rates. Secondary outcomes were toxicity, cosmesis and quality of life.

In total, 34 studies were eligible for analysis, of which 5 reported on repeat breast-conserving surgery (BCS) alone, 10 with mixed populations (BCS +/- RT and/or mastectomy), 18 on repeat BCS followed by re irradiation (whole-breast or partial) and one on quality of life. The weighted estimates for 5-year overall survival for repeat BCS and repeat BCS followed by reirradiation were 77% and 87%, respectively. Five-year local control was 76% for repeat BCS alone and 89% for repeat BCS followed by re-irradiation. Grade III-IV toxicity rates after re-irradiation varied from 0 to 21%, whereas the cosmesis was excellent-good in 29-100% of patients and unacceptable in 0-18%.

Repeat BCS followed by re-irradiation, with either whole breast or partial breast re-irradiation, seems a feasible alternative to mastectomy in case of IBTR, in selected patients. Toxicity rates are low and the cosmetic outcome is good, but the size and follow-up of the published patient series is limited. (C) 2019 Elsevier Ltd, BASO similar to The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved.

Original languageEnglish
Pages (from-to)1317-1327
Number of pages11
JournalEuropean Journal of Surgical Oncology
Volume45
Issue number8
DOIs
Publication statusPublished - Aug 2019

Keywords

  • IBTR
  • Recurrent breast cancer
  • Breast-conserving therapy
  • Repeat breast-conserving therapy
  • Repeat breast irradiation
  • QUALITY-OF-LIFE
  • TERM-FOLLOW-UP
  • 2ND CONSERVATIVE TREATMENT
  • TUMOR RECURRENCE
  • LOCAL RECURRENCE
  • INTRAOPERATIVE RADIOTHERAPY
  • RADIATION-THERAPY
  • WHOLE-BREAST
  • LOCOREGIONAL RECURRENCE
  • SALVAGE MASTECTOMY

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