Repairing injured peripheral nerves: Bridging the gap

Ronald Deumens*, Ahmet Bozkurt, Marcel F. Meek, Marco A. E. Marcus, Elbert A. J. Joosten, Joachim Weis, Gary A. Brook

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

322 Citations (Web of Science)

Abstract

Peripheral nerve injuries that induce gaps larger than 1-2 cm require bridging strategies for repair. Autologous nerve grafts are still the gold standard for such interventions, although alternative treatments, as well as treatments to improve the therapeutic efficacy of autologous nerve grafting are generating increasing interest. Investigations are still mostly experimental, although some clinical studies have been undertaken. In this review, we aim to describe the developments in bridging technology which aim to replace the autograft. A multi-disciplinary approach is of utmost importance to develop and optimise treatments of the most challenging peripheral nerve injuries.
Original languageEnglish
Pages (from-to)245-276
JournalProgress in Neurobiology
Volume92
Issue number3
DOIs
Publication statusPublished - Nov 2010

Keywords

  • Axon regeneration
  • Peripheral nerve injury
  • Nerve grafting
  • Autologous nerves
  • Neurodegeneration
  • Neuropathic pain
  • Nerve guides
  • Nerve repair

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