Abstract
To examine the relationship between filtration fraction and systemic vasculopathy, in normoalbuminuric insulin-dependent diabetic adolescents.We calculated filtration fraction from measured glomerular filtration rate and renal plasma flow during a hypotonic saline perfusion test in 30 normotensive adolescent diabetic patients (9-19 years), with a mean duration of diabetes of 7.4 years. Blood pressure and heart rate were measured in basal conditions, during a 24-h ambulatory monitoring and during a dynamic exercise test on a cycle ergometer and peripheral vascular resistance was calculated.Filtration fraction was increased in the diabetic children compared with controls (30+/-6% vs. 22+/-4%, p
Original language | English |
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Pages (from-to) | 548-551 |
Journal | Acta Paediatrica |
Volume | 96 |
Issue number | 4 |
DOIs | |
Publication status | Published - 1 Jan 2007 |