Renal functional changes in relation to hemodynamic parameters during exercise test in normoalbuminuric insulin-dependent children.

A. Raes, D. Matthys, R.A.M.G. Donckerwolcke, M. Craen, S. van Aken, J. vande Walle

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Abstract

To examine the relationship between filtration fraction and systemic vasculopathy, in normoalbuminuric insulin-dependent diabetic adolescents.We calculated filtration fraction from measured glomerular filtration rate and renal plasma flow during a hypotonic saline perfusion test in 30 normotensive adolescent diabetic patients (9-19 years), with a mean duration of diabetes of 7.4 years. Blood pressure and heart rate were measured in basal conditions, during a 24-h ambulatory monitoring and during a dynamic exercise test on a cycle ergometer and peripheral vascular resistance was calculated.Filtration fraction was increased in the diabetic children compared with controls (30+/-6% vs. 22+/-4%, p
Original languageEnglish
Pages (from-to)548-551
JournalActa Paediatrica
Volume96
Issue number4
DOIs
Publication statusPublished - 1 Jan 2007

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