TY - JOUR
T1 - Renal function in relation to low-level environmental lead exposure
AU - Mujaj, Blerim
AU - Yang, Wen-Yi
AU - Zhang, Zhen-Yu
AU - Wei, Fang-Fei
AU - Thijs, Lutgarde
AU - Verhamme, Peter
AU - Staessen, Jan A.
N1 - Funding Information:
The European Union (HEALTH-F7-305507 HOMAGE) and the European Research Council (Advanced Researcher Grant 2011-294713-EPLORE and Proof-of-Concept Grant 713601-uPROPHET), the European Research Area Net for Cardiovascular Diseases (JTC2017-046-PROACT) and the Fonds voor Wetenschappelijk Onderzoek Vlaanderen, Ministry of the Flemish Community, Brussels, Belgium (G.0881.13) currently support the Research Unit Hypertension and Cardiovascular Research. The sponsors had no role in the preparation of this report.
Funding Information:
In support of SPHERL, the Research Unit Hypertension and Cardiovascular Epidemiology received an unrestricted grant from the International Lead Association (www.ila-lead.org).
Publisher Copyright:
© The Author(s) 2018.
PY - 2019/6
Y1 - 2019/6
N2 - Background Numerous studies suggested that occupational or environmental exposure to lead adversely affects renal function. However, most studies lost relevance because of the substantially lower current environmental lead exposure and all relied on serum creatinine to estimate glomerular filtration. We investigated the association of estimated glomerular filtration rate (eGFR), estimated from serum creatinine, cystatin C or both, with blood lead (BPb) using the baseline measurements of the ongoing Study for Promotion of Health in Recycling Lead (SPHERL; NCT02243904) in newly hired workers prior to significant occupational lead exposure.Methods Among 447 men (participation rate, 82.7%), we assessed the association of eGFR and the urinary albumin-to-creatinine ratio (ACR) with BPb across thirds of the BPb distribution using linear regression analysis. Fully adjusted models accounted for age, blood pressure, body mass index, the waist-to-hip ratio, smoking, the total-to-high-density-lipoprotein ratio, plasma glucose, serum -glutamyltransferase and antihypertensive drug treatment.Results Age averaged 28.7 (SD, 10.2) years (range, 19.1-31.8). Geometric mean BPb concentration was 4.34 g/dL (5th-95th percentile interval, 0.9-14.8). In unadjusted and adjusted analyses, eGFR estimated from serum creatinine [mean (SD), 105.26 (15.2) mL/min/1.73 m(2)], serum cystatin C [mean (SD), 127.8 (13.8) mL/min/1.73 m(2)] or both [mean (SD), 111.9 (14.8) mL/min/1.73 m(2)] was not associated with BPb (P 0.36), whereas ACR [geometric mean, 4.32mg/g (5th-95th percentile interval, 1.91-12.50)] was lower with higher BPb.Conclusions At the BPb levels observed in this study, there was no evidence for an association between renal function and lead exposure.
AB - Background Numerous studies suggested that occupational or environmental exposure to lead adversely affects renal function. However, most studies lost relevance because of the substantially lower current environmental lead exposure and all relied on serum creatinine to estimate glomerular filtration. We investigated the association of estimated glomerular filtration rate (eGFR), estimated from serum creatinine, cystatin C or both, with blood lead (BPb) using the baseline measurements of the ongoing Study for Promotion of Health in Recycling Lead (SPHERL; NCT02243904) in newly hired workers prior to significant occupational lead exposure.Methods Among 447 men (participation rate, 82.7%), we assessed the association of eGFR and the urinary albumin-to-creatinine ratio (ACR) with BPb across thirds of the BPb distribution using linear regression analysis. Fully adjusted models accounted for age, blood pressure, body mass index, the waist-to-hip ratio, smoking, the total-to-high-density-lipoprotein ratio, plasma glucose, serum -glutamyltransferase and antihypertensive drug treatment.Results Age averaged 28.7 (SD, 10.2) years (range, 19.1-31.8). Geometric mean BPb concentration was 4.34 g/dL (5th-95th percentile interval, 0.9-14.8). In unadjusted and adjusted analyses, eGFR estimated from serum creatinine [mean (SD), 105.26 (15.2) mL/min/1.73 m(2)], serum cystatin C [mean (SD), 127.8 (13.8) mL/min/1.73 m(2)] or both [mean (SD), 111.9 (14.8) mL/min/1.73 m(2)] was not associated with BPb (P 0.36), whereas ACR [geometric mean, 4.32mg/g (5th-95th percentile interval, 1.91-12.50)] was lower with higher BPb.Conclusions At the BPb levels observed in this study, there was no evidence for an association between renal function and lead exposure.
KW - BLOOD LEAD
KW - CADMIUM
KW - CHRONIC KIDNEY-DISEASE
KW - IMPAIRMENT
KW - NATIONAL-HEALTH
KW - POPULATION
KW - PRESSURE
KW - SERUM CREATININE
KW - UNITED-STATES
KW - eGFR
KW - environmental exposure
KW - lead
KW - occupational medicine
KW - renal function
U2 - 10.1093/ndt/gfy279
DO - 10.1093/ndt/gfy279
M3 - Article
C2 - 30165570
SN - 0931-0509
VL - 34
SP - 941
EP - 946
JO - Nephrology Dialysis Transplantation
JF - Nephrology Dialysis Transplantation
IS - 6
ER -