Remission of Type 2 Diabetes Mellitus in Patients After Different Types of Bariatric Surgery: A Population-Based Cohort Study in the United Kingdom

J.P. Yska, E.N. van Roon, A. de Boer, H.G.M. Leufkens, B. Wilffert, L.J.M. de Heide, F. de Vries, A. Lalmohamed

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Abstract

IMPORTANCE To our knowledge, an observational study on the remission of type 2 diabetes mellitus (T2DM) after different types of bariatric surgery based on data from general practice has not been carried out. OBJECTIVE To assess the effect of different types of bariatric surgery in patients with T2DM on diabetes remission compared with matched control patients, and the effect of the type of bariatric surgery on improvement of glycemic control and related clinical parameters. DESIGN, SETTING, AND PARTICIPANTS A retrospective cohort study conducted from May 2013 to May 2014 within the Clinical Practice Research Datalink involving 2978 patients with a record of bariatric surgery (2005-2012) and a body mass index (calculated as weight in kilograms divided by height in meters squared) of 35 or greater. We identified 569 patients with T2DM and matched them to 1881 patients with diabetes without bariatric surgery. Data on the use of medication and laboratory results were evaluated. EXPOSURES Bariatric surgery, stratified by type of surgery (gastric banding, Roux-en-Y gastric bypass, sleeve gastrectomy, or other/unknown). MAIN OUTCOMES AND MEASURES Remission of T2DM (complete discontinuation of glycemic therapy, accompanied with a subsequently recorded hemoglobin A(1c) level
Original languageEnglish
Pages (from-to)1126-1133
JournalJAMA Surgery
Volume150
Issue number12
DOIs
Publication statusPublished - 1 Jan 2015

Cite this

Yska, J. P., van Roon, E. N., de Boer, A., Leufkens, H. G. M., Wilffert, B., de Heide, L. J. M., de Vries, F., & Lalmohamed, A. (2015). Remission of Type 2 Diabetes Mellitus in Patients After Different Types of Bariatric Surgery: A Population-Based Cohort Study in the United Kingdom. JAMA Surgery, 150(12), 1126-1133. https://doi.org/10.1001/jamasurg.2015.2398