Relationship of Optic Nerve Structure and Function to Peripapillary Vessel Density Measurements of Optical Coherence Tomography Angiography in Glaucoma

Harsha L. Rao*, Zia S. Pradhan, Robert N. Weinreb, Srilakshmi Dasari, Mohammed Riyazuddin, Sharanya Raveendran, Narendra K. Puttaiah, Jayasree P. Venugopal, Dhanaraj A. S. Rao, Sathi Devi, Kaweh Mansouri, Carroll A. B. Webers

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

38 Citations (Web of Science)


Purpose: To evaluate the sectoral and global structure-structure (vessel density-retinal nerve fiber layer thickness) and structure-function (vessel density-visual sensitivity loss) relationships of peripapillary vessel density measurements on optical coherence tomography angiography in primary open-angle glaucoma and to determine if fractional polynomial (FP) models characterize the relationships better than linear models.

Materials and Methods: In a cross-sectional study, structure-structure and structure-function relationships of peripapillary vessel densities were determined in 227 eyes of 143 subjects (63 control and 164 primary open-angle glaucoma eyes) who had undergone standard automated perimetry and optical coherence tomography testing within 6 months of each other, using linear and FP models. FP model evaluates the relationship between the dependent and the best-fitting fractional powers of the independent variable. Strength of relationship was reported as coefficient of determination (R-2).

Results: R-2 values for structure-structure associations using linear models (0.53 for superotemporal sector, 0.61 for inferotemporal, and 0.53 for average measurements) were significantly less (P

Conclusions: The inferotemporal peripapillary vessel density showed the strongest association with the corresponding retinal nerve fiber layer thickness and visual sensitivity loss in the global and sectoral regions studied. The FP models were significantly better than linear models in describing these relationships.

Original languageEnglish
Pages (from-to)548-554
Number of pages7
JournalJournal of Glaucoma
Issue number6
Publication statusPublished - Jun 2017


  • primary open-angle glaucoma
  • optical coherence tomography angiography
  • structure-function relationship
  • EYES

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