Objective Obesity and liver fat are associated with decreased levels of serum sex hormone binding globulin (SHBG). Laboratory studies suggest that hepatic de novo lipogenesis (DNL) is involved in the downregulation of SHBG synthesis. The aim of the present study was to address the role of DNL on serum SHBG in humans.Design A cross-sectional study examining the association between DNL, measured by stable isotopes, and serum SHBG, stratified by sex.Participants Healthy men (n = 34) and women (n = 21) were combined from two cross-sectional studies. Forty-two per cent of participants had hepatic steatosis, and the majority were overweight (62%) or obese (27%).Results DNL was inversely associated with SHBG in women (beta: -0.015, 95% CI: -0.030; 0.000), but not in men (beta: 0.007, 95% CI: -0.005; 0.019) (p for interaction = .068). Adjustment for study population, age and body mass index did not materially change these results, although statistical significance was lost after adjustment for serum insulin.Conclusions An inverse association between DNL and SHBG may explain the decreased SHBG levels that are observed in obesity, at least in women.
Original languageEnglish
Pages (from-to)101-106
Number of pages6
JournalClinical Endocrinology
Issue number1
Publication statusPublished - 1 Jul 2021


  • de novo lipogenesis
  • liver fat
  • non&#8208
  • alcoholic fatty liver disease
  • polycystic ovary syndrome
  • sex hormone binding globulin
  • stable isotopes


Dive into the research topics of 'Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans'. Together they form a unique fingerprint.

Cite this