Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans

P.I.H.G. Simons; O. Valkenburg; I. Telgenkamp; K.M. van der Waaij; D.M. de Groot; P. Veeraiah; J.A.P. Bons; M.R. Taskinen; J. Boren; P. Schrauwen; J.H.W. Rutten; D. Cassiman; C.G. Schalkwijk; C.D.A. Stehouwer; V.B. Schrauwen-Hinderling; L. Hodson; M.C.G.J. Brouwers

doi:10.1111/cen.14459

Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans

P.I.H.G. Simons, O. Valkenburg, I. Telgenkamp, K.M. van der Waaij, D.M. de Groot, P. Veeraiah, J.A.P. Bons, M.R. Taskinen, J. Boren, P. Schrauwen, J.H.W. Rutten, D. Cassiman, C.G. Schalkwijk, C.D.A. Stehouwer, V.B. Schrauwen-Hinderling, L. Hodson, M.C.G.J. Brouwers^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Objective Obesity and liver fat are associated with decreased levels of serum sex hormone binding globulin (SHBG). Laboratory studies suggest that hepatic de novo lipogenesis (DNL) is involved in the downregulation of SHBG synthesis. The aim of the present study was to address the role of DNL on serum SHBG in humans.Design A cross-sectional study examining the association between DNL, measured by stable isotopes, and serum SHBG, stratified by sex.Participants Healthy men (n = 34) and women (n = 21) were combined from two cross-sectional studies. Forty-two per cent of participants had hepatic steatosis, and the majority were overweight (62%) or obese (27%).Results DNL was inversely associated with SHBG in women (beta: -0.015, 95% CI: -0.030; 0.000), but not in men (beta: 0.007, 95% CI: -0.005; 0.019) (p for interaction = .068). Adjustment for study population, age and body mass index did not materially change these results, although statistical significance was lost after adjustment for serum insulin.Conclusions An inverse association between DNL and SHBG may explain the decreased SHBG levels that are observed in obesity, at least in women.

Original language	English
Pages (from-to)	101-106
Number of pages	6
Journal	Clinical Endocrinology
Volume	95
Issue number	1
DOIs	https://doi.org/10.1111/cen.14459
Publication status	Published - 1 Jul 2021

Keywords

de novo lipogenesis
liver fat
non&#8208
alcoholic fatty liver disease
polycystic ovary syndrome
sex hormone binding globulin
stable isotopes

Access to Document

10.1111/cen.14459Licence: CC BY

Cite this

Simons, P. I. H. G., Valkenburg, O., Telgenkamp, I., van der Waaij, K. M., de Groot, D. M., Veeraiah, P., Bons, J. A. P., Taskinen, M. R., Boren, J., Schrauwen, P., Rutten, J. H. W., Cassiman, D., Schalkwijk, C. G., Stehouwer, C. D. A., Schrauwen-Hinderling, V. B., Hodson, L., & Brouwers, M. C. G. J. (2021). Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans. Clinical Endocrinology, 95(1), 101-106. https://doi.org/10.1111/cen.14459

@article{44ac7e83407545889b3bd786014e47ce,

title = "Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans",

abstract = "Objective Obesity and liver fat are associated with decreased levels of serum sex hormone binding globulin (SHBG). Laboratory studies suggest that hepatic de novo lipogenesis (DNL) is involved in the downregulation of SHBG synthesis. The aim of the present study was to address the role of DNL on serum SHBG in humans.Design A cross-sectional study examining the association between DNL, measured by stable isotopes, and serum SHBG, stratified by sex.Participants Healthy men (n = 34) and women (n = 21) were combined from two cross-sectional studies. Forty-two per cent of participants had hepatic steatosis, and the majority were overweight (62%) or obese (27%).Results DNL was inversely associated with SHBG in women (beta: -0.015, 95% CI: -0.030; 0.000), but not in men (beta: 0.007, 95% CI: -0.005; 0.019) (p for interaction = .068). Adjustment for study population, age and body mass index did not materially change these results, although statistical significance was lost after adjustment for serum insulin.Conclusions An inverse association between DNL and SHBG may explain the decreased SHBG levels that are observed in obesity, at least in women.",

keywords = "de novo lipogenesis, liver fat, non&#8208, alcoholic fatty liver disease, polycystic ovary syndrome, sex hormone binding globulin, stable isotopes",

author = "P.I.H.G. Simons and O. Valkenburg and I. Telgenkamp and {van der Waaij}, K.M. and {de Groot}, D.M. and P. Veeraiah and J.A.P. Bons and M.R. Taskinen and J. Boren and P. Schrauwen and J.H.W. Rutten and D. Cassiman and C.G. Schalkwijk and C.D.A. Stehouwer and V.B. Schrauwen-Hinderling and L. Hodson and M.C.G.J. Brouwers",

year = "2021",

month = jul,

day = "1",

doi = "10.1111/cen.14459",

language = "English",

volume = "95",

pages = "101--106",

journal = "Clinical Endocrinology",

issn = "0300-0664",

publisher = "Wiley-Blackwell",

number = "1",

}

Simons, PIHG , Valkenburg, O, Telgenkamp, I, van der Waaij, KM, de Groot, DM, Veeraiah, P , Bons, JAP, Taskinen, MR, Boren, J, Schrauwen, P, Rutten, JHW, Cassiman, D, Schalkwijk, CG , Stehouwer, CDA , Schrauwen-Hinderling, VB, Hodson, L & Brouwers, MCGJ 2021, 'Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans', Clinical Endocrinology, vol. 95, no. 1, pp. 101-106. https://doi.org/10.1111/cen.14459

TY - JOUR

T1 - Relationship between de novo lipogenesis and serum sex hormone binding globulin in humans

AU - Simons, P.I.H.G.

AU - Valkenburg, O.

AU - Telgenkamp, I.

AU - van der Waaij, K.M.

AU - de Groot, D.M.

AU - Veeraiah, P.

AU - Bons, J.A.P.

AU - Taskinen, M.R.

AU - Boren, J.

AU - Schrauwen, P.

AU - Rutten, J.H.W.

AU - Cassiman, D.

AU - Schalkwijk, C.G.

AU - Stehouwer, C.D.A.

AU - Schrauwen-Hinderling, V.B.

AU - Hodson, L.

AU - Brouwers, M.C.G.J.

PY - 2021/7/1

Y1 - 2021/7/1

N2 - Objective Obesity and liver fat are associated with decreased levels of serum sex hormone binding globulin (SHBG). Laboratory studies suggest that hepatic de novo lipogenesis (DNL) is involved in the downregulation of SHBG synthesis. The aim of the present study was to address the role of DNL on serum SHBG in humans.Design A cross-sectional study examining the association between DNL, measured by stable isotopes, and serum SHBG, stratified by sex.Participants Healthy men (n = 34) and women (n = 21) were combined from two cross-sectional studies. Forty-two per cent of participants had hepatic steatosis, and the majority were overweight (62%) or obese (27%).Results DNL was inversely associated with SHBG in women (beta: -0.015, 95% CI: -0.030; 0.000), but not in men (beta: 0.007, 95% CI: -0.005; 0.019) (p for interaction = .068). Adjustment for study population, age and body mass index did not materially change these results, although statistical significance was lost after adjustment for serum insulin.Conclusions An inverse association between DNL and SHBG may explain the decreased SHBG levels that are observed in obesity, at least in women.

AB - Objective Obesity and liver fat are associated with decreased levels of serum sex hormone binding globulin (SHBG). Laboratory studies suggest that hepatic de novo lipogenesis (DNL) is involved in the downregulation of SHBG synthesis. The aim of the present study was to address the role of DNL on serum SHBG in humans.Design A cross-sectional study examining the association between DNL, measured by stable isotopes, and serum SHBG, stratified by sex.Participants Healthy men (n = 34) and women (n = 21) were combined from two cross-sectional studies. Forty-two per cent of participants had hepatic steatosis, and the majority were overweight (62%) or obese (27%).Results DNL was inversely associated with SHBG in women (beta: -0.015, 95% CI: -0.030; 0.000), but not in men (beta: 0.007, 95% CI: -0.005; 0.019) (p for interaction = .068). Adjustment for study population, age and body mass index did not materially change these results, although statistical significance was lost after adjustment for serum insulin.Conclusions An inverse association between DNL and SHBG may explain the decreased SHBG levels that are observed in obesity, at least in women.

KW - de novo lipogenesis

KW - liver fat

KW - non&#8208

KW - alcoholic fatty liver disease

KW - polycystic ovary syndrome

KW - sex hormone binding globulin

KW - stable isotopes

U2 - 10.1111/cen.14459

DO - 10.1111/cen.14459

M3 - Article

C2 - 33715205

SN - 0300-0664

VL - 95

SP - 101

EP - 106

JO - Clinical Endocrinology

JF - Clinical Endocrinology

IS - 1

ER -