Relation between platelet coagulant and vascular function, sex-specific analysis in adult survivors of childhood cancer compared to a population-based sample

Marina Panova-Noeva*, Bianca Wagner, Markus Nagler, Natalie Arnold, Juergen H. Prochaska, Susan Eckerle, Henri M. Spronk, Hiltrud Merzenich, Arthur Wingerter, Astrid Schneider, Sven Danckwardt, Hugo ten Cate, Joerg Faber, Philipp S. Wild

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Female sex is a risk factor for long-term adverse outcome in cancer survivors, however very little is known for the underlying pathophysiological mechanisms rendering the increased risk. This study investigated sex-specifically the relation between thrombin generation (TG) with and without presence of platelets and vascular function in 200 adult survivors of a childhood cancer compared to 335 population-based control individuals. TG lag time, peak height and endogenous thrombin potential (ETP) measured in presence and absence of platelets were correlated to reflection index (RI) and stiffness index (SI). A sex-specific correlation analysis showed a negative relation in female survivors for platelet-dependent peak height and/or ETP and RI only. An age adjusted linear regression model confirmed the negative association between RI and platelet-dependent ETP (beta estimate: -6.85, 95% confidence interval: -12.19,-1.51) in females. Adjustment for cardiovascular risk factors resulted in loss of the association, whereby arterial hypertension and obesity showed the largest effects on the observed association. No other relevant associations were found in male and female cancer survivors and all population-based controls. This study demonstrates a link between platelet coagulant and vascular function of resistance vessels, found in female cancer survivors, potentially mediated by the presence of arterial hypertension and obesity.

Original languageEnglish
Article number20090
Number of pages9
JournalScientific Reports
Volume9
DOIs
Publication statusPublished - 27 Dec 2019

Keywords

  • THROMBIN GENERATION
  • MORTALITY

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