Regulation of skeletal muscle oxidative phenotype by hypoxia - implications for COPD

I.G.M. Slot

Research output: ThesisDoctoral ThesisInternal

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Abstract

Many people suffering from chronic obstructive pulmonary disease (COPD) have not only low oxygen levels, but also impaired muscle function, which reduces their ability to perform daily activities. It is common knowledge that in advanced stages of COPD, the energy balance is disturbed. This doctoral research project studied the possibility of hypoxia causing these disturbances. First, it was shown that muscle metabolism is disturbed even in patients suffering from mild to moderate COPD and moderate hypoxia, although to a lesser extent than in patients suffering from advanced COPD. Next, experimental models showed that hypoxia does have the potential to cause these metabolic disturbances. They also showed the molecular mechanisms underlying this process.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
Supervisors/Advisors
  • Schols, Annemie, Supervisor
  • Gosker, Harry, Advisor
Award date8 Oct 2015
Place of PublicationMaastricht
Publisher
Print ISBNs9789462038783
Publication statusPublished - 2015

Keywords

  • COPD
  • muscle metabolism
  • hypoxia

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