Abstract
Early delivery occurs increasingly often and involves underdeveloped lungs. Normally, lungs mature in the womb, but in the case of early delivery the maturing process takes place outside this protective environment. The most vulnerable infants receive at this stage so-called “surfactant therapy”, which facilitates the breathing, as well as mechanical respiration. However, applying therapies to these delicate lungs can unintentionally cause damage. This dissertation describes studies into the functions of the surfactant and shows that this therapy can keep inflammatory reactions within bounds. By means of a cell cultivation model that imitates the pulmonary alveoli, this dissertation shows also for the first time that surfactant has a positive influence on the wound recovery.
Original language | English |
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Qualification | Doctor of Philosophy |
Awarding Institution |
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Supervisors/Advisors |
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Award date | 24 Oct 2012 |
Place of Publication | Maastricht |
Publisher | |
Print ISBNs | 9789461591654 |
DOIs | |
Publication status | Published - 1 Jan 2012 |
Keywords
- early delivery
- lung development
- artificial respiration
- surfactant
- wound recovery
- inflammation