Regulation of re-epithelialization and immune modulation by surfactant, surfactant protein A and transforming growth factor β

C.H.M.P. Willems

Research output: ThesisDoctoral ThesisInternal

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Early delivery occurs increasingly often and involves underdeveloped lungs. Normally, lungs mature in the womb, but in the case of early delivery the maturing process takes place outside this protective environment. The most vulnerable infants receive at this stage so-called “surfactant therapy”, which facilitates the breathing, as well as mechanical respiration. However, applying therapies to these delicate lungs can unintentionally cause damage. This dissertation describes studies into the functions of the surfactant and shows that this therapy can keep inflammatory reactions within bounds. By means of a cell cultivation model that imitates the pulmonary alveoli, this dissertation shows also for the first time that surfactant has a positive influence on the wound recovery.
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • Maastricht University
  • Zimmermann, Luc, Supervisor
  • Kramer, Boris, Supervisor
  • van Iwaarden, Freek, Co-Supervisor
Award date24 Oct 2012
Place of PublicationMaastricht
Print ISBNs9789461591654
Publication statusPublished - 1 Jan 2012


  • early delivery
  • lung development
  • artificial respiration
  • surfactant
  • wound recovery
  • inflammation

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