Regulation of fetal gene expression in heart failure

Ellen Dirkx; Paula A. da Costa Martins; Leon J. De Windt

doi:10.1016/j.bbadis.2013.07.023

Regulation of fetal gene expression in heart failure

Ellen Dirkx, Paula A. da Costa Martins, Leon J. De Windt^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

During the processes leading to adverse cardiac remodeling and heart failure, cardiomyocytes react to neurohumoral stimuli and biomechanical stress by activating pathways that induce pathological hypertrophy. The gene expression patterns and molecular changes observed during cardiac hypertrophic remodeling bare resemblance to those observed during fetal cardiac development. The re-activation of fetal genes in the adult failing heart is a complex biological process that involves transcriptional, posttranscriptional and epigenetic regulation of the cardiac genome. In this review, the mechanistic actions of transcription factors, microRNAs and chromatin remodeling processes in regulating fetal gene expression in heart failure are discussed.

Original language	English
Pages (from-to)	2414-2424
Journal	Biochimica et Biophysica Acta-Molecular Basis of Disease
Volume	1832
Issue number	12
DOIs	https://doi.org/10.1016/j.bbadis.2013.07.023
Publication status	Published - Dec 2013

Keywords

Gene regulation
Transcription factors
Epigenetics

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abstract = "During the processes leading to adverse cardiac remodeling and heart failure, cardiomyocytes react to neurohumoral stimuli and biomechanical stress by activating pathways that induce pathological hypertrophy. The gene expression patterns and molecular changes observed during cardiac hypertrophic remodeling bare resemblance to those observed during fetal cardiac development. The re-activation of fetal genes in the adult failing heart is a complex biological process that involves transcriptional, posttranscriptional and epigenetic regulation of the cardiac genome. In this review, the mechanistic actions of transcription factors, microRNAs and chromatin remodeling processes in regulating fetal gene expression in heart failure are discussed. ",

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author = "Ellen Dirkx and {da Costa Martins}, {Paula A.} and {De Windt}, {Leon J.}",

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AU - De Windt, Leon J.

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AB - During the processes leading to adverse cardiac remodeling and heart failure, cardiomyocytes react to neurohumoral stimuli and biomechanical stress by activating pathways that induce pathological hypertrophy. The gene expression patterns and molecular changes observed during cardiac hypertrophic remodeling bare resemblance to those observed during fetal cardiac development. The re-activation of fetal genes in the adult failing heart is a complex biological process that involves transcriptional, posttranscriptional and epigenetic regulation of the cardiac genome. In this review, the mechanistic actions of transcription factors, microRNAs and chromatin remodeling processes in regulating fetal gene expression in heart failure are discussed.

KW - Gene regulation

KW - Transcription factors

KW - Epigenetics

U2 - 10.1016/j.bbadis.2013.07.023

DO - 10.1016/j.bbadis.2013.07.023

M3 - Article

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JO - Biochimica et Biophysica Acta-Molecular Basis of Disease

JF - Biochimica et Biophysica Acta-Molecular Basis of Disease

IS - 12

ER -

Regulation of fetal gene expression in heart failure

Abstract

Keywords

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