Regulated Proteolysis of NOTCH2 and NOTCH3 Receptors by ADAM10 and Presenilins

Keyphrases

• Notch2 100%
• Presenilin 100%
• ADAM10 100%
• Regulated Proteolysis 100%
• NOTCH3 100%
• Ligand Binding 66%
• γ-secretase 66%
• Activation Mechanism 66%
• Notch1 66%
• Notch2 Signaling 66%
• Notch3 Signaling 66%
• Notch Receptors 66%
• Protease 33%
• Transcriptional Activation 33%
• Tissue Homeostasis 33%
• Embryonic Development 33%
• ADAM17 33%
• Membrane Receptors 33%
• Proteolysis 33%
• Adjacent Cell 33%
• Adult Tissues 33%
• ADAM10 Metalloprotease 33%
• Regulated Intramembrane Proteolysis 33%
• Tumor Necrosis Factor-α Converting Enzyme 33%
• Proteolytic Activation 33%
• Intramembranous 33%

Biochemistry, Genetics and Molecular Biology

• Protein Catabolism 100%
• ADAM10 100%
• Presenilin 100%
• Ligand Binding 50%
• Gamma Secretase 50%
• Tumor Necrosis Factor 25%
• Homeostasis 25%
• Tumor Necrosis Factor Alpha 25%
• Enzyme 25%
• Embryogenesis 25%
• Transactivation 25%
• Transmembrane Receptors 25%
• Transcription Initiation 25%
• Metalloendopeptidase 25%
• ADAM17 25%
• Protease 25%

INIS

• receptors 100%
• proteolysis 100%
• ligands 87%
• cleavage 37%
• notches 37%
• humans 12%
• tissues 12%
• proteins 12%
• enzymes 12%
• adults 12%
• mammals 12%
• homeostasis 12%
• tumor necrosis factor 12%
• embryonic development 12%