Regional complexity in enteric neuron wiring reflects diversity of motility patterns in the mouse large intestine

Zhiling Li, Marlene M. Hao, Chris Van den Haute, Veerle Baekelandt, Werend Boesmans*, Pieter Vanden Berghe*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

34 Citations (Web of Science)

Abstract

The enteric nervous system controls a variety of gastrointestinal functions including intestinal motility. The minimal neuronal circuit necessary to direct peristalsis is well-characterized but several intestinal regions display also other motility patterns for which the underlying circuits and connectivity schemes that coordinate the transition between those patterns are poorly understood. We investigated whether in regions with a richer palette of motility patterns, the underlying nerve circuits reflect this complexity. Using Ca2+ imaging, we determined the location and response fingerprint of large populations of enteric neurons upon focal network stimulation. Complemented by neuronal tracing and volumetric reconstructions of synaptic contacts, this shows that the multifunctional proximal colon requires specific additional circuit components as compared to the distal colon, where peristalsis is the predominant motility pattern. Our study reveals that motility control is hard-wired in the enteric neural networks and that circuit complexity matches the motor pattern portfolio of specific intestinal regions.

Original languageEnglish
Article number42914
Number of pages27
JournalElife
Volume8
DOIs
Publication statusPublished - 12 Feb 2019

Keywords

  • MIGRATING MOTOR COMPLEXES
  • GUINEA-PIG
  • NERVOUS-SYSTEM
  • SYNAPTIC-TRANSMISSION
  • MYENTERIC NEURONS
  • SUBMUCOSAL NEURONS
  • CIRCULAR MUSCLE
  • SENSORY NEURONS
  • PERISTALSIS
  • RECEPTORS

Cite this