Reference Values and Factors Associated With Renal Resistive Index in a Family-Based Population Study

Belen Ponte; Menno Pruijm; Daniel Ackermann; Philippe Vuistiner; Ute Eisenberger; Idris Guessous; Valentin Rousson; Markus G. Mohaupt; Heba Alwan; Georg Ehret; Antoinette Pechere-Bertschi; Fred Paccaud; Jan A. Staessen; Bruno Vogt; Michel Burnier; Pierre-Yves Martin; Murielle Bochud

doi:10.1161/HYPERTENSIONAHA.113.02321

Reference Values and Factors Associated With Renal Resistive Index in a Family-Based Population Study

Belen Ponte^*, Menno Pruijm, Daniel Ackermann, Philippe Vuistiner, Ute Eisenberger, Idris Guessous, Valentin Rousson, Markus G. Mohaupt, Heba Alwan, Georg Ehret, Antoinette Pechere-Bertschi, Fred Paccaud, Jan A. Staessen, Bruno Vogt, Michel Burnier, Pierre-Yves Martin, Murielle Bochud

^*Corresponding author for this work

Epidemiologie

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Increased renal resistive index (RRI) has been recently associated with target organ damage and cardiovascular or renal outcomes in patients with hypertension and diabetes mellitus. However, reference values in the general population and information on familial aggregation are largely lacking. We determined the distribution of RRI, associated factors, and heritability in a population-based study. Families of European ancestry were randomly selected in 3 Swiss cities. Anthropometric parameters and cardiovascular risk factors were assessed. A renal Doppler ultrasound was performed, and RRI was measured in 3 segmental arteries of both kidneys. We used multilevel linear regression analysis to explore the factors associated with RRI, adjusting for center and family relationships. Sex-specific reference values for RRI were generated according to age. Heritability was estimated by variance components using the ASSOC program (SAGE software). Four hundred women (mean age +/- SD, 44.9 +/- 16.7 years) and 326 men (42.1 +/- 16.8 years) with normal renal ultrasound had mean RRI of 0.64 +/- 0.05 and 0.62 +/- 0.05, respectively (P

Original language	English
Pages (from-to)	136-142
Journal	Hypertension
Volume	63
Issue number	1
DOIs	https://doi.org/10.1161/HYPERTENSIONAHA.113.02321
Publication status	Published - Jan 2014

Keywords

reference values
ultrasonography

Access to Document

10.1161/HYPERTENSIONAHA.113.02321

Cite this

Ponte, B., Pruijm, M., Ackermann, D., Vuistiner, P., Eisenberger, U., Guessous, I., Rousson, V., Mohaupt, M. G., Alwan, H., Ehret, G., Pechere-Bertschi, A., Paccaud, F., Staessen, J. A., Vogt, B., Burnier, M., Martin, P.-Y., & Bochud, M. (2014). Reference Values and Factors Associated With Renal Resistive Index in a Family-Based Population Study. Hypertension, 63(1), 136-142. https://doi.org/10.1161/HYPERTENSIONAHA.113.02321

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title = "Reference Values and Factors Associated With Renal Resistive Index in a Family-Based Population Study",

abstract = "Increased renal resistive index (RRI) has been recently associated with target organ damage and cardiovascular or renal outcomes in patients with hypertension and diabetes mellitus. However, reference values in the general population and information on familial aggregation are largely lacking. We determined the distribution of RRI, associated factors, and heritability in a population-based study. Families of European ancestry were randomly selected in 3 Swiss cities. Anthropometric parameters and cardiovascular risk factors were assessed. A renal Doppler ultrasound was performed, and RRI was measured in 3 segmental arteries of both kidneys. We used multilevel linear regression analysis to explore the factors associated with RRI, adjusting for center and family relationships. Sex-specific reference values for RRI were generated according to age. Heritability was estimated by variance components using the ASSOC program (SAGE software). Four hundred women (mean age +/- SD, 44.9 +/- 16.7 years) and 326 men (42.1 +/- 16.8 years) with normal renal ultrasound had mean RRI of 0.64 +/- 0.05 and 0.62 +/- 0.05, respectively (P",

keywords = "reference values, ultrasonography",

author = "Belen Ponte and Menno Pruijm and Daniel Ackermann and Philippe Vuistiner and Ute Eisenberger and Idris Guessous and Valentin Rousson and Mohaupt, {Markus G.} and Heba Alwan and Georg Ehret and Antoinette Pechere-Bertschi and Fred Paccaud and Staessen, {Jan A.} and Bruno Vogt and Michel Burnier and Pierre-Yves Martin and Murielle Bochud",

year = "2014",

month = jan,

doi = "10.1161/HYPERTENSIONAHA.113.02321",

language = "English",

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Ponte, B, Pruijm, M, Ackermann, D, Vuistiner, P, Eisenberger, U, Guessous, I, Rousson, V, Mohaupt, MG, Alwan, H, Ehret, G, Pechere-Bertschi, A, Paccaud, F, Staessen, JA, Vogt, B, Burnier, M, Martin, P-Y & Bochud, M 2014, 'Reference Values and Factors Associated With Renal Resistive Index in a Family-Based Population Study', Hypertension, vol. 63, no. 1, pp. 136-142. https://doi.org/10.1161/HYPERTENSIONAHA.113.02321

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T1 - Reference Values and Factors Associated With Renal Resistive Index in a Family-Based Population Study

AU - Ponte, Belen

AU - Pruijm, Menno

AU - Ackermann, Daniel

AU - Vuistiner, Philippe

AU - Eisenberger, Ute

AU - Guessous, Idris

AU - Rousson, Valentin

AU - Mohaupt, Markus G.

AU - Alwan, Heba

AU - Ehret, Georg

AU - Pechere-Bertschi, Antoinette

AU - Paccaud, Fred

AU - Staessen, Jan A.

AU - Vogt, Bruno

AU - Burnier, Michel

AU - Martin, Pierre-Yves

AU - Bochud, Murielle

PY - 2014/1

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N2 - Increased renal resistive index (RRI) has been recently associated with target organ damage and cardiovascular or renal outcomes in patients with hypertension and diabetes mellitus. However, reference values in the general population and information on familial aggregation are largely lacking. We determined the distribution of RRI, associated factors, and heritability in a population-based study. Families of European ancestry were randomly selected in 3 Swiss cities. Anthropometric parameters and cardiovascular risk factors were assessed. A renal Doppler ultrasound was performed, and RRI was measured in 3 segmental arteries of both kidneys. We used multilevel linear regression analysis to explore the factors associated with RRI, adjusting for center and family relationships. Sex-specific reference values for RRI were generated according to age. Heritability was estimated by variance components using the ASSOC program (SAGE software). Four hundred women (mean age +/- SD, 44.9 +/- 16.7 years) and 326 men (42.1 +/- 16.8 years) with normal renal ultrasound had mean RRI of 0.64 +/- 0.05 and 0.62 +/- 0.05, respectively (P

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KW - ultrasonography

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DO - 10.1161/HYPERTENSIONAHA.113.02321

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