Reference Values and Factors Associated With Renal Resistive Index in a Family-Based Population Study

Belen Ponte*, Menno Pruijm, Daniel Ackermann, Philippe Vuistiner, Ute Eisenberger, Idris Guessous, Valentin Rousson, Markus G. Mohaupt, Heba Alwan, Georg Ehret, Antoinette Pechere-Bertschi, Fred Paccaud, Jan A. Staessen, Bruno Vogt, Michel Burnier, Pierre-Yves Martin, Murielle Bochud

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Increased renal resistive index (RRI) has been recently associated with target organ damage and cardiovascular or renal outcomes in patients with hypertension and diabetes mellitus. However, reference values in the general population and information on familial aggregation are largely lacking. We determined the distribution of RRI, associated factors, and heritability in a population-based study. Families of European ancestry were randomly selected in 3 Swiss cities. Anthropometric parameters and cardiovascular risk factors were assessed. A renal Doppler ultrasound was performed, and RRI was measured in 3 segmental arteries of both kidneys. We used multilevel linear regression analysis to explore the factors associated with RRI, adjusting for center and family relationships. Sex-specific reference values for RRI were generated according to age. Heritability was estimated by variance components using the ASSOC program (SAGE software). Four hundred women (mean age +/- SD, 44.9 +/- 16.7 years) and 326 men (42.1 +/- 16.8 years) with normal renal ultrasound had mean RRI of 0.64 +/- 0.05 and 0.62 +/- 0.05, respectively (P
Original languageEnglish
Pages (from-to)136-142
Issue number1
Publication statusPublished - Jan 2014


  • reference values
  • ultrasonography

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