Reference curve for the first-year growth response to growth hormone treatment in prepubertal children with idiopathic growth hormone deficiency: validation of the KIGS first-year growth response curve using the Belgian Register for the Study of Growth and Puberty Problems

S. Straetemans, M. Roelants, M. Thomas, R. Rooman, J. de Schepper

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Abstract

BACKGROUND: Comparing observed and expected growth after first-year growth hormone (GH) therapy is useful for identifying a poor growth response to GH. AIM: To generate a first-year, age-specific growth response reference curve for prepubertal Belgian children with idiopathic growth hormone deficiency (iGHD) treated with a standard weight-adjusted GH dose and to compare this national reference with the response references derived from KIGS. SUBJECTS AND METHODS: First-year height data of 357 prepubertal children (240 males) with iGHD were analyzed. Smooth reference curves of first-year height velocity (HV) in relation to age were created. Differences with the KIGS targets were evaluated after z-score transformation. RESULTS: The observed first-year HVs were log-normal distributed by age and decreased significantly with age (p<0.001). No GH dose or gender effect was observed (p=0.5). Distance to target height, severity of GHD and occurrence of multiple pituitary hormone deficiencies had a positive effect (p<0.01) on the calculated HV SDS. When applying the KIGS targets for severe iGHD, mean HV SDS was close to zero (-0.09+/-0.84). CONCLUSION: The developed age-specific growth response curves enable rapid identification of poor response to first-year GH treatment in prepubertal iGHD children. Our results validate the published growth targets derived from the KIGS database.
Original languageEnglish
Pages (from-to)343-349
Number of pages7
JournalHormone Research in Paediatrics
Volume81
Issue number5
DOIs
Publication statusPublished - 1 Jan 2014

Keywords

  • Growth hormone deficiency
  • Growth response
  • Growth targets
  • Growth hormone therapy
  • GH DEFICIENCY
  • ADULT HEIGHT
  • PREDICTION MODEL
  • GESTATIONAL-AGE
  • FINAL HEIGHT
  • STANDARDS

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