Reductions in body weight and insulin resistance are not associated with changes in grey matter volume or cortical thickness during the PREVIEW study

M Drummen, A Heinecke, E Dorenbos, A Vreugdenhil, A Raben, M S Westerterp-Plantenga, T C Adam

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

INTRODUCTION: The effect of changes in body weight or insulin resistance on grey matter volume and cortical thickness change are unclear. The present observational study assessed effects of an 8-week weight loss period (≥8% of body weight), and a subsequent 22-month weight maintenance period on grey matter volume and cortical thickness.

METHODS: A total of 24 participants (12f/12 m; age 52.8 ± 10.6 years) with overweight/obesity and pre-diabetes were recruited. T1-weighted magnetic resonance imaging was used to determine grey matter volume and cortical thickness at baseline, after the weight loss period and after a medium to high dietary protein weight maintenance period.

RESULTS: At baseline, global grey matter volume was inversely associated with HOMA-IR, adjusted for sex and age (r = -0.42; p = .049). During the weight loss period participants decreased their BMI (32.1 ± 3.3 to 28.1 ± 2.8 kg/m2, p < .01), body-fat (41.6 ± 6.4 to 35.0 ± 8.0%, p < .01) and insulin resistance (HOMA-IR: 4.0 ± 2.0 to 1.8 ± 0.9, p < .01). During the 22-month weight maintenance period, these parameters gradually increased again (BMI: 29.3 ± 3.8 kg/m2; body-fat: 37.8 ± 9.3%; HOMA-IR: 2.9 ± 1.4, p < .01). Global grey matter volume and cortical thickness did not change significantly during the weight loss or weight maintenance period. Changes in body weight, body-fat percentage or insulin sensitivity were not associated with changes in global grey matter volume.

CONCLUSION: In conclusion, we confirmed that global grey brain matter volume was inversely associated with insulin resistance at baseline, yet an intervention yielding a decrease in insulin resistance did not lead to changes in global grey brain matter volume or cortical thickness.

TRIAL REGISTRATION: The trial is registered with ClinicalTrials.gov, NCT01777893.

Original languageEnglish
Pages (from-to)106-111
Number of pages6
JournalJournal of the Neurological Sciences
Volume403
Early online date14 Jun 2019
DOIs
Publication statusPublished - 15 Aug 2019

Keywords

  • MRI
  • Cortical thickness
  • Grey matter volume
  • BMI
  • Insulin resistance
  • Weight loss
  • GRAY-MATTER
  • MASS INDEX
  • DIFFERENTIAL ASSOCIATIONS
  • BRAIN
  • OBESITY
  • FAT
  • INFLAMMATION
  • INCREASES
  • DISEASE
  • ATROPHY

Cite this

@article{3467abfa23514af78b9c174bb38cf145,
title = "Reductions in body weight and insulin resistance are not associated with changes in grey matter volume or cortical thickness during the PREVIEW study",
abstract = "INTRODUCTION: The effect of changes in body weight or insulin resistance on grey matter volume and cortical thickness change are unclear. The present observational study assessed effects of an 8-week weight loss period (≥8{\%} of body weight), and a subsequent 22-month weight maintenance period on grey matter volume and cortical thickness.METHODS: A total of 24 participants (12f/12 m; age 52.8 ± 10.6 years) with overweight/obesity and pre-diabetes were recruited. T1-weighted magnetic resonance imaging was used to determine grey matter volume and cortical thickness at baseline, after the weight loss period and after a medium to high dietary protein weight maintenance period.RESULTS: At baseline, global grey matter volume was inversely associated with HOMA-IR, adjusted for sex and age (r = -0.42; p = .049). During the weight loss period participants decreased their BMI (32.1 ± 3.3 to 28.1 ± 2.8 kg/m2, p < .01), body-fat (41.6 ± 6.4 to 35.0 ± 8.0{\%}, p < .01) and insulin resistance (HOMA-IR: 4.0 ± 2.0 to 1.8 ± 0.9, p < .01). During the 22-month weight maintenance period, these parameters gradually increased again (BMI: 29.3 ± 3.8 kg/m2; body-fat: 37.8 ± 9.3{\%}; HOMA-IR: 2.9 ± 1.4, p < .01). Global grey matter volume and cortical thickness did not change significantly during the weight loss or weight maintenance period. Changes in body weight, body-fat percentage or insulin sensitivity were not associated with changes in global grey matter volume.CONCLUSION: In conclusion, we confirmed that global grey brain matter volume was inversely associated with insulin resistance at baseline, yet an intervention yielding a decrease in insulin resistance did not lead to changes in global grey brain matter volume or cortical thickness.TRIAL REGISTRATION: The trial is registered with ClinicalTrials.gov, NCT01777893.",
keywords = "MRI, Cortical thickness, Grey matter volume, BMI, Insulin resistance, Weight loss, GRAY-MATTER, MASS INDEX, DIFFERENTIAL ASSOCIATIONS, BRAIN, OBESITY, FAT, INFLAMMATION, INCREASES, DISEASE, ATROPHY",
author = "M Drummen and A Heinecke and E Dorenbos and A Vreugdenhil and A Raben and Westerterp-Plantenga, {M S} and Adam, {T C}",
note = "Copyright {\circledC} 2019 Elsevier B.V. All rights reserved.",
year = "2019",
month = "8",
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doi = "10.1016/j.jns.2019.06.017",
language = "English",
volume = "403",
pages = "106--111",
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TY - JOUR

T1 - Reductions in body weight and insulin resistance are not associated with changes in grey matter volume or cortical thickness during the PREVIEW study

AU - Drummen, M

AU - Heinecke, A

AU - Dorenbos, E

AU - Vreugdenhil, A

AU - Raben, A

AU - Westerterp-Plantenga, M S

AU - Adam, T C

N1 - Copyright © 2019 Elsevier B.V. All rights reserved.

PY - 2019/8/15

Y1 - 2019/8/15

N2 - INTRODUCTION: The effect of changes in body weight or insulin resistance on grey matter volume and cortical thickness change are unclear. The present observational study assessed effects of an 8-week weight loss period (≥8% of body weight), and a subsequent 22-month weight maintenance period on grey matter volume and cortical thickness.METHODS: A total of 24 participants (12f/12 m; age 52.8 ± 10.6 years) with overweight/obesity and pre-diabetes were recruited. T1-weighted magnetic resonance imaging was used to determine grey matter volume and cortical thickness at baseline, after the weight loss period and after a medium to high dietary protein weight maintenance period.RESULTS: At baseline, global grey matter volume was inversely associated with HOMA-IR, adjusted for sex and age (r = -0.42; p = .049). During the weight loss period participants decreased their BMI (32.1 ± 3.3 to 28.1 ± 2.8 kg/m2, p < .01), body-fat (41.6 ± 6.4 to 35.0 ± 8.0%, p < .01) and insulin resistance (HOMA-IR: 4.0 ± 2.0 to 1.8 ± 0.9, p < .01). During the 22-month weight maintenance period, these parameters gradually increased again (BMI: 29.3 ± 3.8 kg/m2; body-fat: 37.8 ± 9.3%; HOMA-IR: 2.9 ± 1.4, p < .01). Global grey matter volume and cortical thickness did not change significantly during the weight loss or weight maintenance period. Changes in body weight, body-fat percentage or insulin sensitivity were not associated with changes in global grey matter volume.CONCLUSION: In conclusion, we confirmed that global grey brain matter volume was inversely associated with insulin resistance at baseline, yet an intervention yielding a decrease in insulin resistance did not lead to changes in global grey brain matter volume or cortical thickness.TRIAL REGISTRATION: The trial is registered with ClinicalTrials.gov, NCT01777893.

AB - INTRODUCTION: The effect of changes in body weight or insulin resistance on grey matter volume and cortical thickness change are unclear. The present observational study assessed effects of an 8-week weight loss period (≥8% of body weight), and a subsequent 22-month weight maintenance period on grey matter volume and cortical thickness.METHODS: A total of 24 participants (12f/12 m; age 52.8 ± 10.6 years) with overweight/obesity and pre-diabetes were recruited. T1-weighted magnetic resonance imaging was used to determine grey matter volume and cortical thickness at baseline, after the weight loss period and after a medium to high dietary protein weight maintenance period.RESULTS: At baseline, global grey matter volume was inversely associated with HOMA-IR, adjusted for sex and age (r = -0.42; p = .049). During the weight loss period participants decreased their BMI (32.1 ± 3.3 to 28.1 ± 2.8 kg/m2, p < .01), body-fat (41.6 ± 6.4 to 35.0 ± 8.0%, p < .01) and insulin resistance (HOMA-IR: 4.0 ± 2.0 to 1.8 ± 0.9, p < .01). During the 22-month weight maintenance period, these parameters gradually increased again (BMI: 29.3 ± 3.8 kg/m2; body-fat: 37.8 ± 9.3%; HOMA-IR: 2.9 ± 1.4, p < .01). Global grey matter volume and cortical thickness did not change significantly during the weight loss or weight maintenance period. Changes in body weight, body-fat percentage or insulin sensitivity were not associated with changes in global grey matter volume.CONCLUSION: In conclusion, we confirmed that global grey brain matter volume was inversely associated with insulin resistance at baseline, yet an intervention yielding a decrease in insulin resistance did not lead to changes in global grey brain matter volume or cortical thickness.TRIAL REGISTRATION: The trial is registered with ClinicalTrials.gov, NCT01777893.

KW - MRI

KW - Cortical thickness

KW - Grey matter volume

KW - BMI

KW - Insulin resistance

KW - Weight loss

KW - GRAY-MATTER

KW - MASS INDEX

KW - DIFFERENTIAL ASSOCIATIONS

KW - BRAIN

KW - OBESITY

KW - FAT

KW - INFLAMMATION

KW - INCREASES

KW - DISEASE

KW - ATROPHY

U2 - 10.1016/j.jns.2019.06.017

DO - 10.1016/j.jns.2019.06.017

M3 - Article

C2 - 31255969

VL - 403

SP - 106

EP - 111

JO - Journal of the Neurological Sciences

JF - Journal of the Neurological Sciences

SN - 0022-510X

ER -