Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naive/memory Breg ratio during a relapse but not in remission

S. Knippenberg; E. Peelen; J. Smolders; M.M.G.L. Thewissen; P.P.C.A. Menheere; J.W. Tervaert; R.M.M. Hupperts; J.G.M.C. Damoiseaux

doi:10.1016/j.jneuroim.2011.08.019

Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naive/memory Breg ratio during a relapse but not in remission

S. Knippenberg^*
, E. Peelen
, J. Smolders
, M.M.G.L. Thewissen
, P.P.C.A. Menheere
, J.W. Tervaert
, R.M.M. Hupperts
, J.G.M.C. Damoiseaux

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In this study, we assessed B cell subsets, including Bregs, during stable and active disease in relapsing remitting multiple sclerosis (RRMS) patients and related B cell subsets to vitamin D status. We report that RRMS patients have a decreased percentage of both memory B cells and Bregs compared to healthy controls. During a relapse, the reduction in Bregs involved in particular naive Bregs. We found no correlation between vitamin D status and B cell subsets. An effect of vitamin D on Bregs cannot be ruled out, since it might be the function that is interfered with instead of relative numbers.

Original language	English
Pages (from-to)	80-86
Number of pages	7
Journal	Journal of Neuroimmunology
Volume	239
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2011.08.019
Publication status	Published - 28 Oct 2011

Keywords

Multiple sclerosis
B cell
Regulatory B cell
Vitamin D
EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS
1,25-DIHYDROXYVITAMIN D-3
MEMORY
RITUXIMAB
SUBSETS
DIFFERENTIATION
NATALIZUMAB
PROFILES

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10.1016/j.jneuroim.2011.08.019

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Knippenberg, S., Peelen, E., Smolders, J., Thewissen, M. M. G. L., Menheere, P. P. C. A., Tervaert, J. W., Hupperts, R. M. M., & Damoiseaux, J. G. M. C. (2011). Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naive/memory Breg ratio during a relapse but not in remission. Journal of Neuroimmunology, 239(1-2), 80-86. https://doi.org/10.1016/j.jneuroim.2011.08.019

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title = "Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naive/memory Breg ratio during a relapse but not in remission",

abstract = "In this study, we assessed B cell subsets, including Bregs, during stable and active disease in relapsing remitting multiple sclerosis (RRMS) patients and related B cell subsets to vitamin D status. We report that RRMS patients have a decreased percentage of both memory B cells and Bregs compared to healthy controls. During a relapse, the reduction in Bregs involved in particular naive Bregs. We found no correlation between vitamin D status and B cell subsets. An effect of vitamin D on Bregs cannot be ruled out, since it might be the function that is interfered with instead of relative numbers.",

keywords = "Multiple sclerosis, B cell, Regulatory B cell, Vitamin D, EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS, 1,25-DIHYDROXYVITAMIN D-3, MEMORY, RITUXIMAB, SUBSETS, DIFFERENTIATION, NATALIZUMAB, PROFILES",

author = "S. Knippenberg and E. Peelen and J. Smolders and M.M.G.L. Thewissen and P.P.C.A. Menheere and J.W. Tervaert and R.M.M. Hupperts and J.G.M.C. Damoiseaux",

year = "2011",

month = oct,

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doi = "10.1016/j.jneuroim.2011.08.019",

language = "English",

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journal = "Journal of Neuroimmunology",

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Knippenberg, S, Peelen, E, Smolders, J, Thewissen, MMGL, Menheere, PPCA, Tervaert, JW , Hupperts, RMM & Damoiseaux, JGMC 2011, 'Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naive/memory Breg ratio during a relapse but not in remission', Journal of Neuroimmunology, vol. 239, no. 1-2, pp. 80-86. https://doi.org/10.1016/j.jneuroim.2011.08.019

TY - JOUR

T1 - Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naive/memory Breg ratio during a relapse but not in remission

AU - Knippenberg, S.

AU - Peelen, E.

AU - Smolders, J.

AU - Thewissen, M.M.G.L.

AU - Menheere, P.P.C.A.

AU - Tervaert, J.W.

AU - Hupperts, R.M.M.

AU - Damoiseaux, J.G.M.C.

PY - 2011/10/28

Y1 - 2011/10/28

N2 - In this study, we assessed B cell subsets, including Bregs, during stable and active disease in relapsing remitting multiple sclerosis (RRMS) patients and related B cell subsets to vitamin D status. We report that RRMS patients have a decreased percentage of both memory B cells and Bregs compared to healthy controls. During a relapse, the reduction in Bregs involved in particular naive Bregs. We found no correlation between vitamin D status and B cell subsets. An effect of vitamin D on Bregs cannot be ruled out, since it might be the function that is interfered with instead of relative numbers.

AB - In this study, we assessed B cell subsets, including Bregs, during stable and active disease in relapsing remitting multiple sclerosis (RRMS) patients and related B cell subsets to vitamin D status. We report that RRMS patients have a decreased percentage of both memory B cells and Bregs compared to healthy controls. During a relapse, the reduction in Bregs involved in particular naive Bregs. We found no correlation between vitamin D status and B cell subsets. An effect of vitamin D on Bregs cannot be ruled out, since it might be the function that is interfered with instead of relative numbers.

KW - Multiple sclerosis

KW - B cell

KW - Regulatory B cell

KW - Vitamin D

KW - EXPERIMENTAL AUTOIMMUNE ENCEPHALOMYELITIS

KW - 1,25-DIHYDROXYVITAMIN D-3

KW - MEMORY

KW - RITUXIMAB

KW - SUBSETS

KW - DIFFERENTIATION

KW - NATALIZUMAB

KW - PROFILES

U2 - 10.1016/j.jneuroim.2011.08.019

DO - 10.1016/j.jneuroim.2011.08.019

M3 - Article

C2 - 21940055

SN - 0165-5728

VL - 239

SP - 80

EP - 86

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -

Reduction in IL-10 producing B cells (Breg) in multiple sclerosis is accompanied by a reduced naive/memory Breg ratio during a relapse but not in remission

Abstract

Keywords

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