Reduced thymic expression of ErbB receptors without auto-antibodies against synaptic ErbB in myasthenia gravis

Kathleen Vrolix; Erik H. Niks; Rozen Le Panse; Monique M. van Ostaijen-ten Dam; Anne-Hilde Muris; Cornelia M. Jol-van der Zijde; Maarten J. D. van Tol; Mario Losen; Peter C. Molenaar; Everardus J. J. van Zoelen; Sonia Berrih-Aknin; Marc H. De Baets; Jan J. G. M. Verschuuren; Pilar Martinez-Martinez

doi:10.1016/j.jneuroim.2010.10.024

Reduced thymic expression of ErbB receptors without auto-antibodies against synaptic ErbB in myasthenia gravis

Kathleen Vrolix, Erik H. Niks, Rozen Le Panse, Monique M. van Ostaijen-ten Dam, Anne-Hilde Muris, Cornelia M. Jol-van der Zijde, Maarten J. D. van Tol, Mario Losen, Peter C. Molenaar, Everardus J. J. van Zoelen, Sonia Berrih-Aknin, Marc H. De Baets, Jan J. G. M. Verschuuren, Pilar Martinez-Martinez^*

^*Corresponding author for this work

MHeNs School for Mental Health and Neuroscience

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

In myasthenia gravis (MG), the neuromuscular transmission is impaired mainly by auto-antibodies against the acetylcholine receptor (AChR) or MuSK. In about 5% of the MG patients, however, the auto-antigen is still unknown. We investigated whether these idiopathic MG patients (iMG) have auto-antibodies against ErbB proteins, which influence the AChR density at the NMJ. Our results show reduced mRNA expression levels of ErbB4 in thymus tissue of iMG patients compared to AChR-MG and non-MG patients, but we could not detect anti-ErbB antibodies in sera of iMG patients. Therefore, our results do not support a role for ErbB receptors as auto-antigens in iMG patients.

Original language	English
Pages (from-to)	158-165
Journal	Journal of Neuroimmunology
Volume	232
Issue number	1-2
DOIs	https://doi.org/10.1016/j.jneuroim.2010.10.024
Publication status	Published - Mar 2011

Keywords

Myasthenia gravis
Auto-antibodies
Neuromuscular junction
ErbB

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10.1016/j.jneuroim.2010.10.024

Cite this

Vrolix, K., Niks, E. H., Le Panse, R., van Ostaijen-ten Dam, M. M., Muris, A.-H., Jol-van der Zijde, C. M., van Tol, M. J. D., Losen, M., Molenaar, P. C., van Zoelen, E. J. J., Berrih-Aknin, S., De Baets, M. H., Verschuuren, J. J. G. M., & Martinez-Martinez, P. (2011). Reduced thymic expression of ErbB receptors without auto-antibodies against synaptic ErbB in myasthenia gravis. Journal of Neuroimmunology, 232(1-2), 158-165. https://doi.org/10.1016/j.jneuroim.2010.10.024

@article{11040309ef204e469ddcc2fcde3e5a23,

title = "Reduced thymic expression of ErbB receptors without auto-antibodies against synaptic ErbB in myasthenia gravis",

abstract = "In myasthenia gravis (MG), the neuromuscular transmission is impaired mainly by auto-antibodies against the acetylcholine receptor (AChR) or MuSK. In about 5% of the MG patients, however, the auto-antigen is still unknown. We investigated whether these idiopathic MG patients (iMG) have auto-antibodies against ErbB proteins, which influence the AChR density at the NMJ. Our results show reduced mRNA expression levels of ErbB4 in thymus tissue of iMG patients compared to AChR-MG and non-MG patients, but we could not detect anti-ErbB antibodies in sera of iMG patients. Therefore, our results do not support a role for ErbB receptors as auto-antigens in iMG patients. ",

keywords = "Myasthenia gravis, Auto-antibodies, Neuromuscular junction, ErbB",

author = "Kathleen Vrolix and Niks, {Erik H.} and {Le Panse}, Rozen and {van Ostaijen-ten Dam}, {Monique M.} and Anne-Hilde Muris and {Jol-van der Zijde}, {Cornelia M.} and {van Tol}, {Maarten J. D.} and Mario Losen and Molenaar, {Peter C.} and {van Zoelen}, {Everardus J. J.} and Sonia Berrih-Aknin and {De Baets}, {Marc H.} and Verschuuren, {Jan J. G. M.} and Pilar Martinez-Martinez",

year = "2011",

month = mar,

doi = "10.1016/j.jneuroim.2010.10.024",

language = "English",

volume = "232",

pages = "158--165",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

publisher = "Elsevier",

number = "1-2",

}

Vrolix, K, Niks, EH, Le Panse, R, van Ostaijen-ten Dam, MM, Muris, A-H, Jol-van der Zijde, CM, van Tol, MJD, Losen, M , Molenaar, PC, van Zoelen, EJJ, Berrih-Aknin, S, De Baets, MH, Verschuuren, JJGM & Martinez-Martinez, P 2011, 'Reduced thymic expression of ErbB receptors without auto-antibodies against synaptic ErbB in myasthenia gravis', Journal of Neuroimmunology, vol. 232, no. 1-2, pp. 158-165. https://doi.org/10.1016/j.jneuroim.2010.10.024

TY - JOUR

T1 - Reduced thymic expression of ErbB receptors without auto-antibodies against synaptic ErbB in myasthenia gravis

AU - Vrolix, Kathleen

AU - Niks, Erik H.

AU - Le Panse, Rozen

AU - van Ostaijen-ten Dam, Monique M.

AU - Muris, Anne-Hilde

AU - Jol-van der Zijde, Cornelia M.

AU - van Tol, Maarten J. D.

AU - Losen, Mario

AU - Molenaar, Peter C.

AU - van Zoelen, Everardus J. J.

AU - Berrih-Aknin, Sonia

AU - De Baets, Marc H.

AU - Verschuuren, Jan J. G. M.

AU - Martinez-Martinez, Pilar

PY - 2011/3

Y1 - 2011/3

N2 - In myasthenia gravis (MG), the neuromuscular transmission is impaired mainly by auto-antibodies against the acetylcholine receptor (AChR) or MuSK. In about 5% of the MG patients, however, the auto-antigen is still unknown. We investigated whether these idiopathic MG patients (iMG) have auto-antibodies against ErbB proteins, which influence the AChR density at the NMJ. Our results show reduced mRNA expression levels of ErbB4 in thymus tissue of iMG patients compared to AChR-MG and non-MG patients, but we could not detect anti-ErbB antibodies in sera of iMG patients. Therefore, our results do not support a role for ErbB receptors as auto-antigens in iMG patients.

AB - In myasthenia gravis (MG), the neuromuscular transmission is impaired mainly by auto-antibodies against the acetylcholine receptor (AChR) or MuSK. In about 5% of the MG patients, however, the auto-antigen is still unknown. We investigated whether these idiopathic MG patients (iMG) have auto-antibodies against ErbB proteins, which influence the AChR density at the NMJ. Our results show reduced mRNA expression levels of ErbB4 in thymus tissue of iMG patients compared to AChR-MG and non-MG patients, but we could not detect anti-ErbB antibodies in sera of iMG patients. Therefore, our results do not support a role for ErbB receptors as auto-antigens in iMG patients.

KW - Myasthenia gravis

KW - Auto-antibodies

KW - Neuromuscular junction

KW - ErbB

U2 - 10.1016/j.jneuroim.2010.10.024

DO - 10.1016/j.jneuroim.2010.10.024

M3 - Article

C2 - 21168922

SN - 0165-5728

VL - 232

SP - 158

EP - 165

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

IS - 1-2

ER -