Reduced metal ion concentrations in atherosclerotic plaques from subjects with Type 2 diabetes mellitus

Nadina Stadler; Sylvia Heeneman; Stefan Voo; Naomi Stanley; Gregory I. Giles; Bevan P. Gang; Kevin D. Croft; Trevor A. Mori; Vladimir Vacata; Mat J. A. P. Daemen; Johannes Waltenberger; Michael J. Davies

doi:10.1016/j.atherosclerosis.2012.03.015

Reduced metal ion concentrations in atherosclerotic plaques from subjects with Type 2 diabetes mellitus

Nadina Stadler, Sylvia Heeneman, Stefan Voo, Naomi Stanley, Gregory I. Giles, Bevan P. Gang, Kevin D. Croft, Trevor A. Mori, Vladimir Vacata, Mat J. A. P. Daemen, Johannes Waltenberger, Michael J. Davies^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Aims: Transition metal ions have been implicated in atherosclerosis. The goal of this study was to investigate whether metal ion levels were higher in people with diabetes, in view of their increased risk of aggravated atherosclerosis. Methods and results: Absolute concentrations of iron, copper, zinc and calcium, and products of protein and lipid oxidation were quantified in atherosclerotic lesions from subjects with (T2DM, n = 27), without Type 2 diabetes (nonDM, n = 22), or hyperglycaemia (HG, n = 17). Iron (P

Original language	English
Pages (from-to)	512-518
Journal	Atherosclerosis
Volume	222
Issue number	2
DOIs	https://doi.org/10.1016/j.atherosclerosis.2012.03.015
Publication status	Published - Jun 2012

Keywords

Iron
Metal ions
Type 2 diabetes
Oxidation
Lipid oxidation
Protein oxidation
Zinc
Calcium

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10.1016/j.atherosclerosis.2012.03.015

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Stadler, N., Heeneman, S., Voo, S., Stanley, N., Giles, G. I., Gang, B. P., Croft, K. D., Mori, T. A., Vacata, V., Daemen, M. J. A. P., Waltenberger, J., & Davies, M. J. (2012). Reduced metal ion concentrations in atherosclerotic plaques from subjects with Type 2 diabetes mellitus. Atherosclerosis, 222(2), 512-518. https://doi.org/10.1016/j.atherosclerosis.2012.03.015

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title = "Reduced metal ion concentrations in atherosclerotic plaques from subjects with Type 2 diabetes mellitus",

abstract = "Aims: Transition metal ions have been implicated in atherosclerosis. The goal of this study was to investigate whether metal ion levels were higher in people with diabetes, in view of their increased risk of aggravated atherosclerosis. Methods and results: Absolute concentrations of iron, copper, zinc and calcium, and products of protein and lipid oxidation were quantified in atherosclerotic lesions from subjects with (T2DM, n = 27), without Type 2 diabetes (nonDM, n = 22), or hyperglycaemia (HG, n = 17). Iron (P",

keywords = "Iron, Metal ions, Type 2 diabetes, Oxidation, Lipid oxidation, Protein oxidation, Zinc, Calcium",

author = "Nadina Stadler and Sylvia Heeneman and Stefan Voo and Naomi Stanley and Giles, {Gregory I.} and Gang, {Bevan P.} and Croft, {Kevin D.} and Mori, {Trevor A.} and Vladimir Vacata and Daemen, {Mat J. A. P.} and Johannes Waltenberger and Davies, {Michael J.}",

year = "2012",

month = jun,

doi = "10.1016/j.atherosclerosis.2012.03.015",

language = "English",

volume = "222",

pages = "512--518",

journal = "Atherosclerosis",

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TY - JOUR

T1 - Reduced metal ion concentrations in atherosclerotic plaques from subjects with Type 2 diabetes mellitus

AU - Stadler, Nadina

AU - Heeneman, Sylvia

AU - Voo, Stefan

AU - Stanley, Naomi

AU - Giles, Gregory I.

AU - Gang, Bevan P.

AU - Croft, Kevin D.

AU - Mori, Trevor A.

AU - Vacata, Vladimir

AU - Daemen, Mat J. A. P.

AU - Waltenberger, Johannes

AU - Davies, Michael J.

PY - 2012/6

Y1 - 2012/6

N2 - Aims: Transition metal ions have been implicated in atherosclerosis. The goal of this study was to investigate whether metal ion levels were higher in people with diabetes, in view of their increased risk of aggravated atherosclerosis. Methods and results: Absolute concentrations of iron, copper, zinc and calcium, and products of protein and lipid oxidation were quantified in atherosclerotic lesions from subjects with (T2DM, n = 27), without Type 2 diabetes (nonDM, n = 22), or hyperglycaemia (HG, n = 17). Iron (P

AB - Aims: Transition metal ions have been implicated in atherosclerosis. The goal of this study was to investigate whether metal ion levels were higher in people with diabetes, in view of their increased risk of aggravated atherosclerosis. Methods and results: Absolute concentrations of iron, copper, zinc and calcium, and products of protein and lipid oxidation were quantified in atherosclerotic lesions from subjects with (T2DM, n = 27), without Type 2 diabetes (nonDM, n = 22), or hyperglycaemia (HG, n = 17). Iron (P

KW - Iron

KW - Metal ions

KW - Type 2 diabetes

KW - Oxidation

KW - Lipid oxidation

KW - Protein oxidation

KW - Zinc

KW - Calcium

U2 - 10.1016/j.atherosclerosis.2012.03.015

DO - 10.1016/j.atherosclerosis.2012.03.015

M3 - Article

C2 - 22521900

SN - 0021-9150

VL - 222

SP - 512

EP - 518

JO - Atherosclerosis

JF - Atherosclerosis

IS - 2

ER -

Reduced metal ion concentrations in atherosclerotic plaques from subjects with Type 2 diabetes mellitus

Abstract

Keywords

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