Reduced metal ion concentrations in atherosclerotic plaques from subjects with Type 2 diabetes mellitus

Nadina Stadler, Sylvia Heeneman, Stefan Voo, Naomi Stanley, Gregory I. Giles, Bevan P. Gang, Kevin D. Croft, Trevor A. Mori, Vladimir Vacata, Mat J. A. P. Daemen, Johannes Waltenberger, Michael J. Davies*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

8 Citations (Web of Science)


Aims: Transition metal ions have been implicated in atherosclerosis. The goal of this study was to investigate whether metal ion levels were higher in people with diabetes, in view of their increased risk of aggravated atherosclerosis. Methods and results: Absolute concentrations of iron, copper, zinc and calcium, and products of protein and lipid oxidation were quantified in atherosclerotic lesions from subjects with (T2DM, n = 27), without Type 2 diabetes (nonDM, n = 22), or hyperglycaemia (HG, n = 17). Iron (P
Original languageEnglish
Pages (from-to)512-518
Issue number2
Publication statusPublished - Jun 2012


  • Iron
  • Metal ions
  • Type 2 diabetes
  • Oxidation
  • Lipid oxidation
  • Protein oxidation
  • Zinc
  • Calcium

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