Abstract
We evaluated outcomes and associated prognostic factors in 233 patients undergoing allogeneic hematopoietic cell transplantation (HCT) for primary myelofibrosis (MF) using reduced-intensity conditioning (RIC). The median age at RIC HCT was 55 yr. Donors were a matched sibling donor (MSD) in 34% of RIC HO's, an HLA well-matched unrelated donor CURD) in 45%, and a partially matched/mismatched URD in 21%. Risk stratification according to the Dynamic International Prognostic Scoring System (DIPSS) was 12% low, 49% intermediate-1, 37% intermediate-2, and 1% high. The probability of survival at 5 yr was 47% (95% confidence interval [CI], 40% to 53%). In a multivariate analysis, donor type was the sole independent factor associated with survival. Adjusted probabilities of survival at 5-yr were 56% (95% CI, 44% to 67%) for MSD, 48% (95% CI, 37% to 58%) for well-matched URD, and 34% (95% CI, 21% to 47%) for partially matched/mismatched URD (P =.002). The relative risk (RR) for NRM was 3.92 (P =.006) for well-matched URD and 9.37 (P
Original language | English |
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Pages (from-to) | 89-97 |
Journal | Biology of Blood and Marrow Transplantation |
Volume | 20 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 2014 |
Keywords
- Myelofibrosis
- Allogeneic transplantation
- Reduced intensity
- Prognosis