Reduced glycaemic and insulinaemic responses following trehalose ingestion: implications for postprandial substrate use

J.G. van Can*, T.H. Ijzerman, L.J. van Loon, F. Brouns, E.E. Blaak

*Corresponding author for this work

    Research output: Contribution to journalArticleAcademicpeer-review


    The proposed impact of slowly digestible sources of dietary carbohydrate in reducing the risk of developing obesity and related metabolic disorders remains unclear. The aim of the present study was to compare the postprandial metabolic response to the ingestion of glucose v. trehalose. We hypothesised that the reduced digestion and absorption rate of trehalose is accompanied by an attenuated glycaemic and insulinaemic response, leading to a less inhibited postprandial fat oxidation rate. In a randomised, single-blind, cross-over study, ten overweight subjects ingested two carbohydrate drinks (75 g carbohydrate equivalents of trehalose or glucose) following an overnight fast (08.40 hours) and together with a standardised mixed meal (12.30 hours; 25 % total energy content was provided as either glucose or trehalose). Blood samples were collected before ingestion and every 30 min thereafter for a period of 3 h; substrate use was assessed by indirect calorimetry and expired breath samples were collected. Ingestion of carbohydrates with a mixed meal resulted in a lower peak glucose response and a lower change in area under the curve (DeltaAUC) following trehalose when compared with glucose. Differences in peak insulin response and DeltaAUC were observed with trehalose when compared with glucose during the morning and afternoon. These differences were accompanied with a reduced carbohydrate oxidation after trehalose when ingested as a drink, whilst no significant differences in fat oxidation between drink were observed.
    Original languageEnglish
    Pages (from-to)1395-1399
    JournalBritish Journal of Nutrition
    Issue number10
    Publication statusPublished - 1 Jan 2009

    Cite this