Reduced behavioural effectiveness of ACTH1-24 after a second administration: interaction with opiates

J. Jolles; V.M. Wiegant; W.H. Gispen

doi:10.1016/0304-3940(78)90083-6

Reduced behavioural effectiveness of ACTH1-24 after a second administration: interaction with opiates

J. Jolles
, V.M. Wiegant
, W.H. Gispen

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Repeated intraventricular administration of ACHT results in reduction of subsequent ACTH-induced grooming behavior. A previous injection of β-endorphin, (D-Phe7)ACTH4−10, or morphine, also reduces the behavioral response to a subsequent injection of ACTH. The reduction in grooming as a result of repeated administration is not mediated by corticosteroid feedback and can be eliminated by pretreatment with the opiate antagonist naloxone.

Original language	English
Pages (from-to)	261-266
Number of pages	6
Journal	Neuroscience Letters
Volume	9
Issue number	2-3
DOIs	https://doi.org/10.1016/0304-3940(78)90083-6
Publication status	Published - 1 Jan 1978

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title = "Reduced behavioural effectiveness of ACTH1-24 after a second administration: interaction with opiates",

abstract = "Repeated intraventricular administration of ACHT results in reduction of subsequent ACTH-induced grooming behavior. A previous injection of β-endorphin, (D-Phe7)ACTH4−10, or morphine, also reduces the behavioral response to a subsequent injection of ACTH. The reduction in grooming as a result of repeated administration is not mediated by corticosteroid feedback and can be eliminated by pretreatment with the opiate antagonist naloxone.",

author = "J. Jolles and V.M. Wiegant and W.H. Gispen",

year = "1978",

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AU - Wiegant, V.M.

AU - Gispen, W.H.

PY - 1978/1/1

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N2 - Repeated intraventricular administration of ACHT results in reduction of subsequent ACTH-induced grooming behavior. A previous injection of β-endorphin, (D-Phe7)ACTH4−10, or morphine, also reduces the behavioral response to a subsequent injection of ACTH. The reduction in grooming as a result of repeated administration is not mediated by corticosteroid feedback and can be eliminated by pretreatment with the opiate antagonist naloxone.

AB - Repeated intraventricular administration of ACHT results in reduction of subsequent ACTH-induced grooming behavior. A previous injection of β-endorphin, (D-Phe7)ACTH4−10, or morphine, also reduces the behavioral response to a subsequent injection of ACTH. The reduction in grooming as a result of repeated administration is not mediated by corticosteroid feedback and can be eliminated by pretreatment with the opiate antagonist naloxone.

U2 - 10.1016/0304-3940(78)90083-6

DO - 10.1016/0304-3940(78)90083-6

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SP - 261

EP - 266

JO - Neuroscience Letters

JF - Neuroscience Letters

IS - 2-3

ER -

Reduced behavioural effectiveness of ACTH1-24 after a second administration: interaction with opiates

Abstract

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