TY - JOUR
T1 - Recurrent pre-eclampsia in women with metabolic syndrome and low plasma volume: aretrospective cohort study
AU - Stekkinger, E.
AU - Scholten, R. R.
AU - Heidema, W. M.
AU - Spaanderman, M. E. A.
PY - 2015/12
Y1 - 2015/12
N2 - Objective To determine the prevalence of recurrent pre-eclampsia in women with a history of pre-eclampsia with both metabolic syndrome and low plasma volume postpartum, as compared with women without either entity. DesignRetrospective cohort study. SettingThree tertiary referral hospitals in the Netherlands. PopulationWomen with a history of pre-eclampsia. MethodsIn 196 women with a history of pre-eclampsia we determined the presence or absence of metabolic syndrome using the World Health Organization criteria and measured plasma volume with the I-125-human serum albumin indicator dilution technique. We compared the prevalence of recurrent pre-eclampsia in four groups, classified according to presence or absence of metabolic syndrome and low or normal plasma volume, calculating odds ratios (OR), adjusted for confounders. Main outcome measureRecurrence of pre-eclampsia in the subsequent pregnancy. ResultsThe prevalence of recurrent pre-eclampsia was 12% (12/99) in women without metabolic syndrome with normal plasma volume, versus 47% (8/17) in women with both metabolic syndrome and low plasma volume: OR 6.44 (95% CI 2.09-19.90), adjusted OR 7.90 (95% CI 2.30-27.16). Recurrent pre-eclampsia was present in 44% (10/23) and 25% (14/57) of women with isolated metabolic syndrome and low plasma volume, respectively. ConclusionsIn the concomitant presence of metabolic syndrome and low plasma volume, the prevalence of recurrent pre-eclampsia was nearly 50%, which is four times as high as the prevalence in women without either entity. Tweetable abstractMetabolic syndrome and low plasma volume raise the risk of recurrent pre-eclampsia to nearly 50%. Tweetable abstract Metabolic syndrome and low plasma volume raise the risk of recurrent pre-eclampsia to nearly 50%.
AB - Objective To determine the prevalence of recurrent pre-eclampsia in women with a history of pre-eclampsia with both metabolic syndrome and low plasma volume postpartum, as compared with women without either entity. DesignRetrospective cohort study. SettingThree tertiary referral hospitals in the Netherlands. PopulationWomen with a history of pre-eclampsia. MethodsIn 196 women with a history of pre-eclampsia we determined the presence or absence of metabolic syndrome using the World Health Organization criteria and measured plasma volume with the I-125-human serum albumin indicator dilution technique. We compared the prevalence of recurrent pre-eclampsia in four groups, classified according to presence or absence of metabolic syndrome and low or normal plasma volume, calculating odds ratios (OR), adjusted for confounders. Main outcome measureRecurrence of pre-eclampsia in the subsequent pregnancy. ResultsThe prevalence of recurrent pre-eclampsia was 12% (12/99) in women without metabolic syndrome with normal plasma volume, versus 47% (8/17) in women with both metabolic syndrome and low plasma volume: OR 6.44 (95% CI 2.09-19.90), adjusted OR 7.90 (95% CI 2.30-27.16). Recurrent pre-eclampsia was present in 44% (10/23) and 25% (14/57) of women with isolated metabolic syndrome and low plasma volume, respectively. ConclusionsIn the concomitant presence of metabolic syndrome and low plasma volume, the prevalence of recurrent pre-eclampsia was nearly 50%, which is four times as high as the prevalence in women without either entity. Tweetable abstractMetabolic syndrome and low plasma volume raise the risk of recurrent pre-eclampsia to nearly 50%. Tweetable abstract Metabolic syndrome and low plasma volume raise the risk of recurrent pre-eclampsia to nearly 50%.
KW - Metabolic syndrome
KW - plasma volume
KW - pre-eclampsia
KW - recurrence
U2 - 10.1111/1471-0528.13737
DO - 10.1111/1471-0528.13737
M3 - Article
C2 - 26589850
SN - 1470-0328
VL - 122
SP - 1773
EP - 1780
JO - Bjog-an International Journal of Obstetrics and Gynaecology
JF - Bjog-an International Journal of Obstetrics and Gynaecology
IS - 13
ER -