Recurrent pre-eclampsia in women with metabolic syndrome and low plasma volume: aretrospective cohort study

E. Stekkinger*, R. R. Scholten, W. M. Heidema, M. E. A. Spaanderman

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Objective To determine the prevalence of recurrent pre-eclampsia in women with a history of pre-eclampsia with both metabolic syndrome and low plasma volume postpartum, as compared with women without either entity. DesignRetrospective cohort study. SettingThree tertiary referral hospitals in the Netherlands. PopulationWomen with a history of pre-eclampsia. MethodsIn 196 women with a history of pre-eclampsia we determined the presence or absence of metabolic syndrome using the World Health Organization criteria and measured plasma volume with the I-125-human serum albumin indicator dilution technique. We compared the prevalence of recurrent pre-eclampsia in four groups, classified according to presence or absence of metabolic syndrome and low or normal plasma volume, calculating odds ratios (OR), adjusted for confounders. Main outcome measureRecurrence of pre-eclampsia in the subsequent pregnancy. ResultsThe prevalence of recurrent pre-eclampsia was 12% (12/99) in women without metabolic syndrome with normal plasma volume, versus 47% (8/17) in women with both metabolic syndrome and low plasma volume: OR 6.44 (95% CI 2.09-19.90), adjusted OR 7.90 (95% CI 2.30-27.16). Recurrent pre-eclampsia was present in 44% (10/23) and 25% (14/57) of women with isolated metabolic syndrome and low plasma volume, respectively. ConclusionsIn the concomitant presence of metabolic syndrome and low plasma volume, the prevalence of recurrent pre-eclampsia was nearly 50%, which is four times as high as the prevalence in women without either entity. Tweetable abstractMetabolic syndrome and low plasma volume raise the risk of recurrent pre-eclampsia to nearly 50%. Tweetable abstract Metabolic syndrome and low plasma volume raise the risk of recurrent pre-eclampsia to nearly 50%.
Original languageEnglish
Pages (from-to)1773-1780
JournalBjog-an International Journal of Obstetrics and Gynaecology
Volume122
Issue number13
DOIs
Publication statusPublished - Dec 2015

Keywords

  • Metabolic syndrome
  • plasma volume
  • pre-eclampsia
  • recurrence

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