TY - JOUR
T1 - Recurrent pericarditis in children and adolescents: a multicentre cohort study
AU - Imazio, Massimo
AU - Brucato, Antonio
AU - Pluymaekers, Nikki
AU - Breda, Luciana
AU - Calabri, Giovanni
AU - Cantarini, Luca
AU - Cimaz, Rolando
AU - Colimodio, Filomena
AU - Corona, Fabrizia
AU - Cumetti, Davide
AU - Lo Cuccio, Chiara Di Blasi
AU - Gattorno, Marco
AU - Insalaco, Antonella
AU - Limongelli, Giuseppe
AU - Russoi, Maria Giovanna
AU - Valenti, Anna
AU - Finkelstein, Yaron
AU - Martini, Alberto
PY - 2016/9
Y1 - 2016/9
N2 - Objective Limited data are available about recurrent pericarditis in children. We sought to explore contemporary causes, characteristics, therapies and outcomes of recurrent pericarditis in paediatric patients. Methods A multicentre (eight sites) cohort study of 110 consecutive cases of paediatric patients with at least two recurrences of pericarditis over an 11-year period (2000-2010) [median 13 years, interquartile range (IQR) 5, 69 boys]. Results Recurrences were idiopathic or viral in 89.1% of cases, followed by postpericardiotomy syndrome (9.1%) and familial Mediterranean fever (0.9%). Recurrent pericarditis was treated with nonsteroidal anti-inflammatory drugs (NSAIDs) in 80.9% of cases, corticosteroids in 64.8% and colchicine was added in 61.8%. Immunosuppressive therapies were administered in 15.5% of patients after subsequent recurrences. After a median follow-up of 60th months, 528 subsequent recurrences were recorded (median 3, range 2-25). Corticosteroid-treated patients experienced more recurrences (standardized risk of recurrence per 100 person-years was 93.2 for patients treated with corticosteroids and 45.2 for those without), side effects and disease-related hospitalizations (for all P
AB - Objective Limited data are available about recurrent pericarditis in children. We sought to explore contemporary causes, characteristics, therapies and outcomes of recurrent pericarditis in paediatric patients. Methods A multicentre (eight sites) cohort study of 110 consecutive cases of paediatric patients with at least two recurrences of pericarditis over an 11-year period (2000-2010) [median 13 years, interquartile range (IQR) 5, 69 boys]. Results Recurrences were idiopathic or viral in 89.1% of cases, followed by postpericardiotomy syndrome (9.1%) and familial Mediterranean fever (0.9%). Recurrent pericarditis was treated with nonsteroidal anti-inflammatory drugs (NSAIDs) in 80.9% of cases, corticosteroids in 64.8% and colchicine was added in 61.8%. Immunosuppressive therapies were administered in 15.5% of patients after subsequent recurrences. After a median follow-up of 60th months, 528 subsequent recurrences were recorded (median 3, range 2-25). Corticosteroid-treated patients experienced more recurrences (standardized risk of recurrence per 100 person-years was 93.2 for patients treated with corticosteroids and 45.2 for those without), side effects and disease-related hospitalizations (for all P
KW - children
KW - corticosteroids
KW - pericarditis
KW - prognosis
KW - recurrent pericarditis
U2 - 10.2459/JCM.0000000000000300
DO - 10.2459/JCM.0000000000000300
M3 - Article
C2 - 27467459
SN - 1558-2027
VL - 17
SP - 707
EP - 712
JO - Journal of Cardiovascular Medicine
JF - Journal of Cardiovascular Medicine
IS - 9
ER -