Rectal and sublingual administration of tacrolimus: a single-dose pharmacokinetic study in healthy volunteers

Keyphrases

• Healthy Volunteers 100%
• Tacrolimus 100%
• Pharmacokinetic Study 100%
• Rectal Administration 100%
• Sublingual Administration 100%
• Clinically Significant 37%
• Oral Administration 37%
• Blood Concentration 25%
• Alternative Formulations 25%
• Pharmacokinetics 25%
• Systemic Exposure 25%
• AIMS™ 12%
• Saliva 12%
• Pharmacokinetic Data 12%
• Oral Cavity 12%
• Route of Administration 12%
• Relative Bioavailability 12%
• Orally Administered 12%
• Systemic Side Effects 12%
• Fixed-dose Combination 12%
• Tongue 12%
• Prograf 12%
• Topical Agents 12%
• Rinsing 12%
• Crossover Study Design 12%
• Mouth Rinsing 12%
• Suppository 12%
• Oral Powder 12%
• Instantaneous Release 12%
• Oral Capsules 12%

INIS

• doses 100%
• rectum 100%
• administration 100%
• oral administration 60%
• rectal administration 60%
• comparative evaluations 40%
• blood 40%
• concentration 40%
• capsules 40%
• powders 40%
• data 20%
• side effects 20%
• design 20%
• randomness 20%
• saliva 20%
• mouth 20%
• oral cavity 20%
• tongue 20%
• biological availability 20%

Pharmacology, Toxicology and Pharmaceutical Science

• Normal Human 100%
• Tacrolimus 100%
• Rectal Administration 100%
• Sublingual Administration 100%
• Pharmacokinetics 100%
• Side Effect 11%
• Immunosuppressive Agent 11%
• Bioavailability 11%
• Route of Administration 11%
• Topical Agent 11%
• Suppository 11%