Recommendations for the conduct of economic evaluations in osteoporosis: outcomes of an experts' consensus meeting organized by the European Society for Clinical and Economic Aspects of Osteoporosis, Osteoarthritis and Musculoskeletal Diseases (ESCEO) and the US branch of the International Osteoporosis Foundation

M. Hiligsmann*, J. -Y. Reginster, A. N. A. Tosteson, S. V. Bukata, K. G. Saag, D. T. Gold, P. Halbout, F. Jiwa, E. M. Lewiecki, D. Pinto, J. D. Adachi, N. Al-Daghri, O. Bruyere, M. Chandran, C. Cooper, N. C. Harvey, T. A. Einhorn, J. A. Kanis, D. L. Kendler, O. D. MessinaR. Rizzoli, L. Si, S. Silverman

*Corresponding author for this work

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Abstract

Economic evaluations are increasingly used to assess the value of health interventions, but variable quality and heterogeneity limit the use of these evaluations by decision-makers. These recommendations provide guidance for the design, conduct, and reporting of economic evaluations in osteoporosis to improve their transparency, comparability, and methodologic standards.IntroductionThis paper aims to provide recommendations for the conduct of economic evaluations in osteoporosis in order to improve their transparency, comparability, and methodologic standards.MethodsA working group was convened by the European Society for Clinical and Economic Aspects of Osteoporosis and Osteoarthritis to make recommendations for the design, conduct, and reporting of economic evaluations in osteoporosis, to define an osteoporosis-specific reference case to serve a minimum standard for all economic analyses in osteoporosis, to discuss methodologic challenges and initiate a call for research. A literature review, a face-to-face meeting in New York City (including 11 experts), and a review/approval by a larger group of experts worldwide (including 23 experts in total) were conducted.ResultsRecommendations on the type of economic evaluation, methods for economic evaluation, modeling aspects, base-case analysis and population, excess mortality, fracture costs and disutility, treatment characteristics, and model validation were provided. Recommendations for reporting economic evaluations in osteoporosis were also made and an osteoporosis-specific checklist was designed that includes items to report when performing an economic evaluation in osteoporosis. Further, 12 minimum criteria for economic evaluations in osteoporosis were identified and 12 methodologic challenges and need for further research were discussed.ConclusionWhile the working group acknowledges challenges and the need for further research, these recommendations are intended to supplement general and national guidelines for economic evaluations, improve transparency, quality, and comparability of economic evaluations in osteoporosis, and maintain methodologic standards to increase their use by decision-makers.

Original languageEnglish
Pages (from-to)45-57
Number of pages13
JournalOsteoporosis International
Volume30
Issue number1
DOIs
Publication statusPublished - Jan 2019

Keywords

  • COST-EFFECTIVENESS ANALYSES
  • Cost-effectiveness
  • EXCESS MORTALITY
  • Economic evaluation
  • FRACTURE RISK REDUCTION
  • HEALTH
  • HIP FRACTURE
  • OLDER WOMEN
  • Osteoporosis
  • POSTMENOPAUSAL WOMEN
  • QUALITY-OF-LIFE
  • Recommendations
  • Reference case
  • TERIPARATIDE
  • VERTEBRAL FRACTURES
  • IMPACT

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