Receptors and signalling mechanisms in the procoagulant response of platelets

J.W.M. Heemskerk, P.R.M. Siljander, E.M. Bevers, R.W. Farndale, T. Lindhout

Research output: Contribution to journalArticleAcademicpeer-review

Abstract

Platelets in an advanced stage of activation change from coagulation-inactive to coagulation-promoting cells. This procoagulant response is characterised by exposure of aminophospholipids, such as phosphatidylserine, to the platelet surface and by formation of microvesicles. Under specific conditions, when both signalling and adhesive platelet receptors are occupied, collagen and also thrombin are able to trigger this response. Thus, platelets express high coagulation-promoting activity only after interacting with multiple receptors.
Original languageEnglish
Pages (from-to)301-306
Number of pages6
JournalPlatelets
Volume11
Issue number6
DOIs
Publication statusPublished - 1 Jan 2000

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