Receptors and signalling mechanisms in the procoagulant response of platelets

J.W.M. Heemskerk; P.R.M. Siljander; E.M. Bevers; R.W. Farndale; T. Lindhout

doi:10.1080/09537100050144704

Receptors and signalling mechanisms in the procoagulant response of platelets

J.W.M. Heemskerk^*, P.R.M. Siljander, E.M. Bevers, R.W. Farndale, T. Lindhout

^*Corresponding author for this work

Research output: Contribution to journal › Article › Academic › peer-review

Abstract

Platelets in an advanced stage of activation change from coagulation-inactive to coagulation-promoting cells. This procoagulant response is characterised by exposure of aminophospholipids, such as phosphatidylserine, to the platelet surface and by formation of microvesicles. Under specific conditions, when both signalling and adhesive platelet receptors are occupied, collagen and also thrombin are able to trigger this response. Thus, platelets express high coagulation-promoting activity only after interacting with multiple receptors.

Original language	English
Pages (from-to)	301-306
Number of pages	6
Journal	Platelets
Volume	11
Issue number	6
DOIs	https://doi.org/10.1080/09537100050144704
Publication status	Published - 1 Jan 2000

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Cite this

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abstract = "Platelets in an advanced stage of activation change from coagulation-inactive to coagulation-promoting cells. This procoagulant response is characterised by exposure of aminophospholipids, such as phosphatidylserine, to the platelet surface and by formation of microvesicles. Under specific conditions, when both signalling and adhesive platelet receptors are occupied, collagen and also thrombin are able to trigger this response. Thus, platelets express high coagulation-promoting activity only after interacting with multiple receptors.",

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AU - Bevers, E.M.

AU - Farndale, R.W.

AU - Lindhout, T.

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N2 - Platelets in an advanced stage of activation change from coagulation-inactive to coagulation-promoting cells. This procoagulant response is characterised by exposure of aminophospholipids, such as phosphatidylserine, to the platelet surface and by formation of microvesicles. Under specific conditions, when both signalling and adhesive platelet receptors are occupied, collagen and also thrombin are able to trigger this response. Thus, platelets express high coagulation-promoting activity only after interacting with multiple receptors.

AB - Platelets in an advanced stage of activation change from coagulation-inactive to coagulation-promoting cells. This procoagulant response is characterised by exposure of aminophospholipids, such as phosphatidylserine, to the platelet surface and by formation of microvesicles. Under specific conditions, when both signalling and adhesive platelet receptors are occupied, collagen and also thrombin are able to trigger this response. Thus, platelets express high coagulation-promoting activity only after interacting with multiple receptors.

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