TY - JOUR
T1 - Receptor guanylyl cyclase (RGC) family in GtoPdb v.2021.3
AU - Beuve, A.
AU - Brouckaert, Peter
AU - Burnett, J.C.
AU - Friebe, Andreas
AU - Garthwaite, John
AU - Hobbs, Adrian J
AU - Koesling, Doris
AU - Kuhn, Michaela
AU - Potter, L.R.
AU - Russwurm, Michael
AU - Schmidt, Harald
AU - Stasch, Johannes-Peter
AU - Waldman, Scott A.
PY - 2021
Y1 - 2021
N2 - The mammalian genome encodes seven guanylyl cyclases, GC-A to GC-G, that are homodimeric transmembrane receptors activated by a diverse range of endogenous ligands. These enzymes convert guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP). GC-A, GC-B and GC-C are expressed predominantly in the cardiovascular system, skeletal system and intestinal epithelium, respectively. GC-D and GC-G are found in the olfactory neuropepithelium and Grueneberg ganglion of rodents, respectively. GC-E and GC-F are expressed in retinal photoreceptors.
AB - The mammalian genome encodes seven guanylyl cyclases, GC-A to GC-G, that are homodimeric transmembrane receptors activated by a diverse range of endogenous ligands. These enzymes convert guanosine-5'-triphosphate to the intracellular second messenger cyclic guanosine-3',5'-monophosphate (cyclic GMP). GC-A, GC-B and GC-C are expressed predominantly in the cardiovascular system, skeletal system and intestinal epithelium, respectively. GC-D and GC-G are found in the olfactory neuropepithelium and Grueneberg ganglion of rodents, respectively. GC-E and GC-F are expressed in retinal photoreceptors.
U2 - 10.2218/gtopdb/F1022/2021.3
DO - 10.2218/gtopdb/F1022/2021.3
M3 - (Systematic) Review article
SN - 2633-1020
VL - 3
SP - 1
EP - 4
JO - IUPHAR/BPS Guide to Pharmacology CITE
JF - IUPHAR/BPS Guide to Pharmacology CITE
ER -