TY - JOUR
T1 - Recent developments in genetics and medically-assisted reproduction: from research to clinical applications
AU - Harper, J.C.
AU - Aittomaki, K.
AU - Borry, P.
AU - Cornel, M.C.
AU - de Wert, G.
AU - Dondorp, W.
AU - Geraedts, J.
AU - Gianaroli, L.
AU - Ketterson, K.
AU - Liebaers, I.
AU - Lundin, K.
AU - Mertes, H.
AU - Morris, M.
AU - Pennings, G.
AU - Sermon, K.
AU - Spits, C.
AU - Soini, S.
AU - van Montfoort, A.P.A.
AU - Veiga, A.
AU - Vermeesch, J.R.
AU - Viville, S.
AU - Macek, M.
AU - European Society of Human Genetics
AU - European Society of Human Reproduction and Embryology and European Society of Human Genetics
PY - 2017
Y1 - 2017
N2 - Two leading European professional societies, the European Society of Human Genetics and the European Society for Human Reproduction and Embryology, have worked together since 2004 to evaluate the impact of fast research advances at the interface of assisted reproduction and genetics, including their application into clinical practice. In September 2016, the expert panel met for the third time. The topics discussed highlighted important issues covering the impacts of expanded carrier screening, direct-to-consumer genetic testing, voiding of the presumed anonymity of gamete donors by advanced genetic testing, advances in the research of genetic causes underlying male and female infertility, utilisation of massively-parallel sequencing in preimplantation genetic testing and non-invasive prenatal screening, mitochondrial replacement in human oocytes, and additionally, issues related to cross-generational epigenetic inheritance following IVF and germline genome editing. The resulting paper represents a consensus of both professional societies involved.
AB - Two leading European professional societies, the European Society of Human Genetics and the European Society for Human Reproduction and Embryology, have worked together since 2004 to evaluate the impact of fast research advances at the interface of assisted reproduction and genetics, including their application into clinical practice. In September 2016, the expert panel met for the third time. The topics discussed highlighted important issues covering the impacts of expanded carrier screening, direct-to-consumer genetic testing, voiding of the presumed anonymity of gamete donors by advanced genetic testing, advances in the research of genetic causes underlying male and female infertility, utilisation of massively-parallel sequencing in preimplantation genetic testing and non-invasive prenatal screening, mitochondrial replacement in human oocytes, and additionally, issues related to cross-generational epigenetic inheritance following IVF and germline genome editing. The resulting paper represents a consensus of both professional societies involved.
KW - assisted reproductive technology
KW - epigenetics
KW - expanded carrier screening
KW - gamete donor anonymity
KW - germline genome editing
KW - female infertility
KW - male infertility
KW - mitochondrial replacement therapy
KW - non-invasive prenatal testing
KW - preimplantation genetic testing
U2 - 10.1093/hropen/hox015
DO - 10.1093/hropen/hox015
M3 - Article
SN - 2399-3529
VL - 2017
JO - Human reproduction open
JF - Human reproduction open
IS - 3
M1 - hox015
ER -