Recent advances in the understanding of immune-mediated nephrotic syndrome: diagnostic and prognostic implications

Sjoerd A. M. E. G. Timmermans, Pieter van Paassen, Jan Willem Cohen Tervaert*

*Corresponding author for this work

Research output: Contribution to journalArticleAcademicpeer-review


Glomerular diseases with severe defects in glomerular permeability give rise to heavy proteinuria and can present as nephrotic syndrome. There are many different causes of the nephrotic syndrome and a renal biopsy is nearly always needed to elucidate the underlying disease. During the last decade, substantial advances have occurred in the understanding of the pathophysiological mechanisms involved in immune-mediated glomerular diseases. Here, we review the diagnostic and prognostic implications of recent progress on the understanding of membranous nephropathy, minimal change disease, focal segmental glomerulosclerosis, amyloidosis, IgA nephropathy and membranoproliferative glomerulonephritis.
Original languageEnglish
Pages (from-to)489-500
JournalExpert Review of Clinical Immunology
Issue number4
Publication statusPublished - Apr 2015


  • amyloidosis
  • diagnostics
  • focal segmental glomerulosclerosis
  • IgA nephropathy
  • membranoproliferative glomerulonephritis
  • membranous nephropathy
  • minimal change disease
  • nephrotic syndrome
  • prognostics

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